Evidence map›Paper›PMID 21911571›Full record

ArticleAntimicrobial agents and chemotherapy2011

Ribosomal mutations as the main cause of macrolide resistance in Campylobacter jejuni and Campylobacter coli.

Mirva Lehtopolku, Pirkko Kotilainen, Marjo Haanperä-Heikkinen, Ulla-Maija Nakari, Marja-Liisa Hänninen, Pentti Huovinen, Anja Siitonen, Erkki Eerola, Jari Jalava, Antti J Hakanen

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Sharing ofmBio · 2025
    Article
  2. Review
  3. Antibiotic Resistance in Bacteria-A Review.Antibiotics (Basel, Switzerland) · 2022
    Review
  4. Article
  5. Prediction of antimicrobial resistance in clinical Campylobacter jejuni isolates from whole-genome sequencing data.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. WGS-Based Prediction and Analysis of Antimicrobial Resistance inFrontiers in cellular and infection microbiology · 2020
    Article
  10. Molecular Basis of Macrolide Resistance inBioMed research international · 2018
    Article
  11. [Gastrointestinal infections].Der Internist · 2017
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Down-regulation of ribosomal protein L22 in non-small cell lung cancer.Medical oncology (Northwood, London, England) · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mirva LehtopolkuAntimicrobial Resistance Unit, National Institute for Health and Welfare, THL, Kiinamyllynkatu 13, 20520 Turku, Finland. mipleht@utu.fi
Pirkko Kotilainen
Marjo Haanperä-Heikkinen
Ulla-Maija Nakari
Marja-Liisa Hänninen
Pentti Huovinen
Anja Siitonen
Erkki Eerola
Jari Jalava
Antti J Hakanen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to examine macrolide resistance mutations in Campylobacter species. In 76 strains studied, point mutation A to G at position 2059 of the 23S rRNA gene was detected in 30 of the 33 erythromycin-resistant strains. An amino acid insertion in the ribosomal protein L22 was found in one resistant strain without a 23S rRNA mutation. The A2059G mutation is the main cause of macrolide resistance in Campylobacter species.

Indexed as

Anti-Bacterial AgentsCampylobacter coliCampylobacter InfectionsCampylobacter jejuniDrug Resistance, BacterialErythromycinHumansMacrolidesMicrobial Sensitivity TestsPoint MutationRibosomal ProteinsRNA, Ribosomal, 23SSequence Analysis, DNAAnti-Bacterial AgentsErythromycinMacrolidesRibosomal ProteinsRNA, Ribosomal, 23S

Identifiers

PMID21911571
PMCPMC3232809

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.