ArticleWestern journal of nursing research2013
Affecting cognition and quality of life via aerobic exercise in Alzheimer's disease.
Article in Western journal of nursing research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05877196 (Precision Medicine in Alzheimer's Disease), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precision Medicine in Alzheimer's Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses (The FIT-AD SMART Trial)
Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Testing the iMplementation Framework fOr behavioral and LIfestyLe interventions in AlZheimer's DiseasE (MOBILIZE) via the ACT randomized controlled trial.Scientific reports · 2025Trial
- The effect of exercise on cerebral blood flow and executive function among young adults: a double-blinded randomized controlled trial.Scientific reports · 2023Trial
- The influence of a 16-week exercise program, APOE status, and age on executive function task performance: A randomized trial.Experimental gerontology · 2021Trial
- Few Structural Brain Changes Associated With Moderate-Intensity Interval Training and Low-Intensity Continuous Training in a Randomized Trial of Fitness and Older Adults.Journal of aging and physical activity · 2021Trial
- Trial
- Feasibility of Conducting Nonpharmacological Interventions to Manage Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial.American journal of Alzheimer's disease and other dementiasTrial
- Efficacy of sequential aerobic exercise and cognitive training in older adults with amnestic mild cognitive impairment.Aging and health research · 2026Article
- Distinct Mechanisms of Multiple Alpha-Band Activities in Frontal Regions Following an 8-Week Medium- (Yoga) and High-Intensity (Pamela) Exercise Intervention.CNS neuroscience & therapeutics · 2025Article
- Identifying exercise and cognitive intervention parameters to optimize executive function in older adults with mild cognitive impairment and dementia: a systematic review and meta-analyses of randomized controlled trials.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease.Dementia & neuropsychologia · 2023Article
- Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies.Neuroscience bulletin · 2019Review
- Article
- The Effects of Multi-Component Exercise Training on Cognitive Functioning and Health-Related Quality of Life in Older Adults.International journal of behavioral medicine · 2018Article
- Cognitive Functioning Differences Between Physically Active and Sedentary Older Adults.Journal of Alzheimer's disease reports · 2018Article
- A 16-Week Aerobic Exercise Intervention Does Not Affect Hippocampal Volume and Cortical Thickness in Mild to Moderate Alzheimer's Disease.Frontiers in aging neuroscience · 2018Article
- Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL/6J mice.Neuroscience · 2012Article
- Feasibility and perception of the impact from aerobic exercise in older adults with Alzheimer's disease.American journal of Alzheimer's disease and other dementias · 2012Article
- Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III).Clinical interventions in aging · 2012Article
- Improving recruitment, retention, and adherence to 6-month cycling in Alzheimer's disease.Geriatric nursing (New York, N.Y.)Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Aerobic exercise is a promising behavioral therapy for Alzheimer's disease (AD), yet few studies have investigated the effect of aerobic exercise on cognition in AD. The purpose of this pilot study was to examine the effect of 6-month aerobic exercise on the change in executive function, global cognition, quality of life (QOL), and depression in community-dwelling older adults with mild to moderate AD. A single group, repeated measures design with outcomes measured at baseline, 3 months, and 6 months was used. Results show that there were no significant changes in any measures except for depression (p = .026). There was a trend toward improvement in executive function and QOL with moderate effect sizes (ESs) and a trend toward deterioration in global cognition with moderate to large ESs. Randomized controlled trials are needed to evaluate the therapeutic effect of aerobic exercise in older adults with AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.