ReviewReproduction (Cambridge, England)2011
Epigenetic reprogramming: is deamination key to active DNA demethylation?
Review in Reproduction (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- DNA Glycosylases Define the Outcome of Endogenous Base Modifications.International journal of molecular sciences · 2023Review
- Specific hypomethylation programs underpin B cell activation in early multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Do Transgenerational Epigenetic Inheritance and Immune System Development Share Common Epigenetic Processes?Journal of developmental biology · 2021Review
- Activation-induced cytidine deaminase is a possible regulator of cross-talk between oocytes and granulosa cells through GDF-9 and SCF feedback system.Scientific reports · 2021Article
- Diuron exposure and Akt overexpression promote glioma formation through DNA hypomethylation.Clinical epigenetics · 2019Article
- TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.Scientific reports · 2019Article
- A Free Radical Scavenger Ameliorates Teratogenic Activity of a DNA Hypomethylating Hematological Therapeutic.Stem cells and development · 2019Article
- Timing of Exposure and Bisphenol-A: Implications for Diabetes Development.Frontiers in endocrinology · 2018Review
- Epigenetic Modulation of Stem Cells in Neurodevelopment: The Role of Methylation and Acetylation.Frontiers in cellular neuroscience · 2017Review
- Bisphenol-A and metabolic diseases: epigenetic, developmental and transgenerational basis.Environmental epigenetics · 2016Review
- Epigenetics in Kidney Transplantation: Current Evidence, Predictions, and Future Research Directions.Transplantation · 2016Review
- Protocadherin17 Promoter Methylation is a Potential Predictive Biomarker in Clear Cell Renal Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Gene activation-associated long noncoding RNAs function in mouse preimplantation development.Development (Cambridge, England) · 2015Article
- Epigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNS.Frontiers in immunology · 2015Review
- Catalytic analysis of APOBEC3G involving real-time NMR spectroscopy reveals nucleic acid determinants for deamination.PloS one · 2015Article
- AID/APOBEC deaminases and cancer.Oncoscience · 2015Review
- Review
- Krüppel like factor 4 promoter undergoes active demethylation during monocyte/macrophage differentiation.PloS one · 2014Article
- Active demethylation in mouse zygotes involves cytosine deamination and base excision repair.Epigenetics & chromatin · 2013Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
DNA demethylation processes are important for reproduction, being central in epigenetic reprogramming during embryonic and germ cell development. While the enzymes methylating DNA have been known for many years, identification of factors capable of mediating active DNA demethylation has been challenging. Recent findings suggest that cytidine deaminases may be key players in active DNA demethylation. One of the most investigated candidates is activation-induced cytidine deaminase (AID), best known for its role in generating secondary antibody diversity in B cells. We evaluate evidence for cytidine deaminases in DNA demethylation pathways in vertebrates and discuss possible models for their targeting and activity regulation. These findings are also considered along with alternative demethylation pathways involving hydroxymethylation.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.