ArticleProceedings of the National Academy of Sciences of the United States of America2011
Compression and self-entanglement of single DNA molecules under uniform electric field.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Generating knotted polymer and protein structures by machine learning.Communications chemistry · 2026Article
- Decoding information stored in DNAs through single-molecule electrical detection platforms.Innovation (Cambridge (Mass.)) · 2025Review
- Effect of Ring Composition on the Statics and Dynamics of Block Copolyelectrolyte Catenanes.Macromolecules · 2025Article
- Article
- Multiphotonic Ablation and Electro-Capacitive Effects Exhibited byBioengineering (Basel, Switzerland) · 2024Article
- Expansion Kinetics of Flexible Polymers upon Release from a Disk-Shaped Confinement.ACS omega · 2024Article
- Expansion of Single Chains Released from a Spherical Cavity.Polymers · 2022Article
- Influence of ionic conditions on knotting in a coarse-grained model for DNA.Frontiers in chemistry · 2022Article
- Channels with Helical Modulation Display Stereospecific Sensitivity for Chiral Superstructures.Polymers · 2021Article
- Polyelectrolyte in Electric Field: Disparate Conformational Behavior along an Aminopolysaccharide Chain.ACS omega · 2020Article
- Complex DNA knots detected with a nanopore sensor.Nature communications · 2019Article
- The Rabl configuration limits topological entanglement of chromosomes in budding yeast.Scientific reports · 2019Article
- Shining a Spotlight on DNA: Single-Molecule Methods to Visualise DNA.Molecules (Basel, Switzerland) · 2019Review
- Article
- KymoKnot: A web server and software package to identify and locate knots in trajectories of linear or circular polymers.The European physical journal. E, Soft matter · 2018Article
- A nanofluidic knot factory based on compression of single DNA in nanochannels.Nature communications · 2018Article
- Are There Knots in Chromosomes?Polymers · 2017Article
- Article
- Direct observation of DNA knots using a solid-state nanopore.Nature nanotechnology · 2016Article
- DNA as a Model for Probing Polymer Entanglements: Circular Polymers and Non-Classical Dynamics.Polymers · 2016Review
Corrections and comments
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We experimentally study the effects of a uniform electric field on the conformation of single DNA molecules. We demonstrate that a moderate electric field (~200 V/cm) strongly compresses isolated DNA polymer coils into isotropic globules. Insight into the nature of these compressed states is gained by following the expansion of the molecules back to equilibrium after halting the electric field. We observe two distinct types of expansion modes: a continuous molecular expansion analogous to a compressed spring expanding, and a much slower expansion characterized by two long-lived metastable states. Fluorescence microscopy and stretching experiments reveal that the metastable states are the result of intramolecular self-entanglements induced by the electric field. These results have broad importance in DNA separations and single molecule genomics, polymer rheology, and DNA-based nanofabrication.
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