ArticleProceedings of the National Academy of Sciences of the United States of America2011
Signature of hydrophobic hydration in a single polymer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 160 citations in OpenAlex.
- Surface Reconstruction in Hydrated Amphiphilic Block Copolymer Thin Films Probed by Fluid Cell Atomic Force Microscopy.Macromolecules · 2026Article
- Extension of the molar absorption coefficient for non-ideal mixtures: an application to aqueous monovalent alcohol solutions.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Gaussian and Non-Gaussian Solvent Density Fluctuations within Solute Cavities in a Water-like Solvent.Journal of chemical theory and computation · 2024Article
- Solvation thermodynamics from cavity shapes of amino acids.PNAS nexus · 2023Article
- Nanopore sensors for single molecular protein detection: Research progress based on computer simulations.IET nanobiotechnology · 2023Review
- Structural features of interfacial water predict the hydrophobicity of chemically heterogeneous surfaces.Chemical science · 2023Article
- Orientational Preferences of GPI-Anchored Ly6/uPAR Proteins.International journal of molecular sciences · 2022Article
- On the Nature of Guest Complexation in Water: Triggered Wetting-Water-Mediated Binding.The journal of physical chemistry. B · 2022Article
- Weakly hydrated anions bind to polymers but not monomers in aqueous solutions.Nature chemistry · 2022Article
- Entropy Analysis of Protein Sequences Reveals a Hierarchical Organization.Entropy (Basel, Switzerland) · 2021Article
- Spontaneous drying of non-polar deep-cavity cavitand pockets in aqueous solution.Nature chemistry · 2020Article
- Mechanical Unfolding of Spectrin Repeats Induces Water-Molecule Ordering.Biophysical journal · 2020Article
- The molecular mechanisms underlying mussel adhesion.Nanoscale advances · 2019Review
- Volumetric and calorimetric properties of aqueous ionene solutions.Journal of molecular liquids · 2017Article
- Molecular Shape and the Hydrophobic Effect.Annual review of physical chemistry · 2016Review
- The hydrophobic effect, and fluctuations: The long and the short of it.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Effects of Mutations on the Reconfiguration Rate of α-Synuclein.The journal of physical chemistry. B · 2015Article
- How osmolytes influence hydrophobic polymer conformations: A unified view from experiment and theory.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Direct observation of dynamic mechanical regulation of DNA condensation by environmental stimuli.Angewandte Chemie (International ed. in English) · 2014Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrophobicity underpins self-assembly in many natural and synthetic molecular and nanoscale systems. A signature of hydrophobicity is its temperature dependence. The first experimental evaluation of the temperature and size dependence of hydration free energy in a single hydrophobic polymer is reported, which tests key assumptions in models of hydrophobic interactions in protein folding. Herein, the hydration free energy required to extend three hydrophobic polymers with differently sized aromatic side chains was directly measured by single molecule force spectroscopy. The results are threefold. First, the hydration free energy per monomer is found to be strongly dependent on temperature and does not follow interfacial thermodynamics. Second, the temperature dependence profiles are distinct among the three hydrophobic polymers as a result of a hydrophobic size effect at the subnanometer scale. Third, the hydration free energy of a monomer on a macromolecule is different from a free monomer; corrections for the reduced hydration free energy due to hydrophobic interaction from neighboring units are required.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.