ArticleProceedings of the National Academy of Sciences of the United States of America2011
Strong reproductive isolation between humans and Neanderthals inferred from observed patterns of introgression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations.International journal of immunogenetics · 2012Guideline
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- Prezygotic barriers effectively limit hybridization in a rapid evolutionary radiation.The New phytologist · 2024Article
- Temporal Variation in Introgressed Segments' Length Statistics Computed from a Limited Number of Ancient Genomes Sheds Light on Past Admixture Pulses.Molecular biology and evolution · 2023Article
- Past human expansions shaped the spatial pattern of Neanderthal ancestry.Science advances · 2023Article
- Article
- Evolution of Homo in the Middle and Late Pleistocene.Journal of human evolution · 2022Review
- Merging morphological and genetic evidence to assess hybridization in Western Eurasian late Pleistocene hominins.Nature ecology & evolution · 2022Article
- Selection against admixture and gene regulatory divergence in a long-term primate field study.Science (New York, N.Y.) · 2022Article
- Inferring archaic introgression from hominin genetic data.Evolutionary anthropology · 2021Review
- Origins of modern human ancestry.Nature · 2021Review
- Sometimes hidden but always there: the assumptions underlying genetic inference of demographic histories.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Harmonizing hybridization dissonance in conservation.Communications biology · 2020Review
- Patterns of mtDNA introgression suggest population replacement in Palaearctic whiskered bat species.Royal Society open science · 2020Article
- Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples.Scientific reports · 2020Article
- SPLATCHE3: simulation of serial genetic data under spatially explicit evolutionary scenarios including long-distance dispersal.Bioinformatics (Oxford, England) · 2019Article
- Whole-Genome Analysis of Introgression Between the Spotted Owl and Barred Owl (G3 (Bethesda, Md.) · 2018Article
- Bayesian estimation of partial population continuity using ancient DNA and spatially explicit simulations.Evolutionary applications · 2018Article
- Mitochondrial genomes uncover the maternal history of the Pamir populations.European journal of human genetics : EJHG · 2018Article
- A parsimonious neutral model suggests Neanderthal replacement was determined by migration and random species drift.Nature communications · 2017Article
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2 authors.
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Abstract
Recent studies have revealed that 2-3% of the genome of non-Africans might come from Neanderthals, suggesting a more complex scenario of modern human evolution than previously anticipated. In this paper, we use a model of admixture during a spatial expansion to study the hybridization of Neanderthals with modern humans during their spread out of Africa. We find that observed low levels of Neanderthal ancestry in Eurasians are compatible with a very low rate of interbreeding (<2%), potentially attributable to a very strong avoidance of interspecific matings, a low fitness of hybrids, or both. These results suggesting the presence of very effective barriers to gene flow between the two species are robust to uncertainties about the exact demography of the Paleolithic populations, and they are also found to be compatible with the observed lack of mtDNA introgression. Our model additionally suggests that similarly low levels of introgression in Europe and Asia may result from distinct admixture events having occurred beyond the Middle East, after the split of Europeans and Asians. This hypothesis could be tested because it predicts that different components of Neanderthal ancestry should be present in Europeans and in Asians.
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