ArticleProceedings of the National Academy of Sciences of the United States of America2011
Testing hypotheses on the rate of molecular evolution in relation to gene expression using microRNAs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Nucleotide substitution rates of diatom plastid encoded protein genes are positively correlated with genome architecture.Scientific reports · 2020Article
- Small RNAs in parasitic nematodes - forms and functions.Parasitology · 2020Review
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- Gene regulatory network stabilized by pervasive weak repressions: microRNA functions revealed by the May-Wigner theory.National science review · 2019Article
- Regulation of Large Number of Weak Targets-New Insights from Twin-microRNAs.Genome biology and evolution · 2018Article
- Expression Variations of miRNAs and mRNAs in Rice (Oryza sativa).Genome biology and evolution · 2016Article
- Comparative genomic analysis of upstream miRNA regulatory motifs in Caenorhabditis.RNA (New York, N.Y.) · 2016Article
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- Determinants of the rate of protein sequence evolution.Nature reviews. Genetics · 2015Review
- Evolutionary Comparison of Two Combinatorial Regulators of SBP-Box Genes, MiR156 and MiR529, in Plants.PloS one · 2015Article
- Microevolution of nematode miRNAs reveals diverse modes of selection.Genome biology and evolution · 2014Article
- Evolutionary interrogation of human biology in well-annotated genomic framework of rhesus macaque.Molecular biology and evolution · 2014Article
- Fast-evolving microRNAs are highly expressed in the early embryo of Drosophila virilis.RNA (New York, N.Y.) · 2014Article
- New microRNAs in Drosophila--birth, death and cycles of adaptive evolution.PLoS genetics · 2014Article
- Pleiotropic constraints, expression level, and the evolution of miRNA sequences.Journal of molecular evolution · 2013Article
- Comparative analysis of human and mouse expression data illuminates tissue-specific evolutionary patterns of miRNAs.Nucleic acids research · 2012Article
- miREvo: an integrative microRNA evolutionary analysis platform for next-generation sequencing experiments.BMC bioinformatics · 2012Article
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10 authors.
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Abstract
There exists an inverse relationship between the rate of molecular evolution and the level of gene expression. Among the many explanations, the "toxic-error" hypothesis is a most general one, which posits that processing errors may often be toxic to the cells. However, toxic errors that constrain the evolution of highly expressed genes are often difficult to measure. In this study, we test the toxic-error hypothesis by using microRNA (miRNA) genes because their processing errors can be directly measured by deep sequencing. A miRNA gene consists of a small mature product (≈22 nt long) and a "backbone." Our analysis shows that (i) like the mature miRNA, the backbone is highly conserved; (ii) the rate of sequence evolution in the backbone is negatively correlated with expression; and (iii) although conserved between distantly related species, the error rate in miRNA processing is also negatively correlated with the expression level. The observations suggest that, as a miRNA gene becomes more highly (or more ubiquitously) expressed, its sequence evolves toward a structure that minimizes processing errors.
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