ArticleNucleic acids research2012
Epigenetic regulation by RARα maintains ligand-independent transcriptional activity.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region.International journal of molecular sciences · 2024Article
- Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway.Cancer science · 2020Article
- Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease.PloS one · 2019Article
- RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells.Nature communications · 2018Article
- Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.The Journal of biological chemistry · 2018Article
- A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans.Genetics · 2017Article
- Intragenic CpG islands play important roles in bivalent chromatin assembly of developmental genes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells.Stem cells international · 2017Review
- Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- [Aberrant DNA methylation and its targeted therapy in acute myeloid leukemia].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.Brain : a journal of neurology · 2015Article
- A spheroid toxicity assay using magnetic 3D bioprinting and real-time mobile device-based imaging.Scientific reports · 2015Article
- Review
- Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.Stem cells (Dayton, Ohio) · 2015Article
- Vitamin A deficiency impairs spatial learning and memory: the mechanism of abnormal CBP-dependent histone acetylation regulated by retinoic acid receptor alpha.Molecular neurobiology · 2015Article
- An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency.The Journal of biological chemistry · 2015Article
- Retinoid receptor signaling and autophagy in acute promyelocytic leukemia.Experimental cell research · 2014Review
- Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Identification and characterization of germ cell genes expressed in the F9 testicular teratoma stem cell line.PloS one · 2014Article
- The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes.Sub-cellular biochemistry · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Retinoic acid receptors (RARs) α, β and γ are key regulators of embryonic development. Hematopoietic differentiation is regulated by RARα, and several types of leukemia show aberrant RARα activity. Through microarray expression analysis, we identified transcripts differentially expressed between F9 wild-type (Wt) and RARα knockout cells cultured in the absence or presence of the RAR-specific ligand all trans retinoic acid (RA). We validated the decreased Mest, Tex13, Gab1, Bcl11a, Tcfap2a and HMGcs1 transcript levels, and increased Slc38a4, Stmn2, RpL39l, Ref2L, Mobp and Rlf1 transcript levels in the RARa knockout cells. The decreased Mest and Tex13 transcript levels were associated with increased promoter CpG-island methylation and increased repressive histone modifications (H3K9me3) in RARα knockout cells. Increased Slc38a4 and Stmn2 transcript levels were associated with decreased promoter CpG-island methylation and increased permissive histone modifications (H3K9/K14ac, H3K4me3) in RARα knockout cells. We demonstrated specific association of RARα and RXRα with the Mest promoter. Importantly, stable expression of a dominant negative, oncogenic PML-RARα fusion protein in F9 Wt cells recapitulated the decreased Mest transcript levels observed in RARα knockout cells. We propose that RARα plays an important role in cellular memory and imprinting by regulating the CpG methylation status of specific promoter regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.