ArticlePediatrics2011
Risk factors for neurotoxicity in newborns with severe neonatal hyperbilirubinemia.
Article in Pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Biological markers of hearing loss in neonates admitted to the neonatal intensive care unit: a systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- Yinzhihuang oral liquid in the treatment of neonatal jaundice: a meta-analysis.Pharmaceutical biology · 2017Pooled it
- Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis.PloS one · 2015Pooled it
- [Effect and safety of intensive phototherapy in treatment of neonatal hyperbilirubinemia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Trial
- Clinical, economic, and organisational impact of the novel AAP 2022 neonatal hyperbilirubinemia guidelines in an Italian third-level neonatology unit.European journal of pediatrics · 2026Observational
- The influencing factors of amplitude-integrated electroencephalography and bilirubin-induced neurological dysfunction scores in neonates with hyperbilirubinemia: a cross-sectional study.BMC pediatrics · 2026Article
- Incidence and risk factors for neonatal jaundice in a teaching hospital in Northern Ghana.BMC pediatrics · 2025Article
- The Severity of Direct Antiglobulin Test Negative ABO Hemolytic Disease of Newborn: A Retrospective Analysis at a Tertiary Children's Hospital.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024Article
- Neonatal jaundice and associated factors in public hospitals of southern Ethiopia: A multi-center cross-sectional study.Heliyon · 2024Article
- Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin.Molecular biology reports · 2023Article
- Neonatal jaundice: magnitude of the problem in Cairo University's neonatal intensive Care unit as a referral center.African health sciences · 2023Article
- Role of transcranial Doppler in assessment of cerebral blood flow in full term neonates with extreme unconjugated hyperbilirubinemia.Journal of ultrasound · 2023Article
- Demystifying non-invasive approaches for screening jaundice in low resource settings: a review.Frontiers in pediatrics · 2023Review
- Clinical and genetic risk factors associated with neonatal severe hyperbilirubinemia: a case-control study based on the China Neonatal Genomes Project.Frontiers in genetics · 2023Article
- Associations between UGT1A1 and SLCO1B1 polymorphisms and susceptibility to neonatal hyperbilirubinemia in Thai population.BMC pediatrics · 2022Article
- Clinical Assessment of Neuroinflammatory Markers and Antioxidants in Neonates with Hyperbilirubinemia and Their Association with Acute Bilirubin Encephalopathy.Children (Basel, Switzerland) · 2022Article
- Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Yinzhihuang Oral Liquid in Treating Neonatal Hyperbilirubinemia.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates.Italian journal of pediatrics · 2021Article
- Causes of severe neonatal hyperbilirubinemia: a multicenter study of three regions in China.World journal of pediatrics : WJP · 2021Observational
- Phototherapy for neonatal hyperbilirubinaemia: Unresolved aspects & future directions.The Indian journal of medical research · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo evaluate the importance of total serum bilirubin (TSB) and neurotoxicity risk factors in predicting acute bilirubin encephalopathy (ABE) at admission or posttreatment bilirubin encephalopathy (BE) in infants with severe hyperbilirubinemia.
methodsWe analyzed the interaction of TSB and risk factors as determinants of ABE and BE in 249 newborns admitted with a TSB level of ≥ 25 mg/dL (427 μmol/L) to Cairo University Children's Hospital during a 12-month period.
resultsAdmission TSB values ranged from 25 to 76.4 mg/dL. Forty-four newborns had moderate or severe ABE at admission; 35 of 249 infants (14%) had evidence of BE at the time of discharge or death. Rh incompatibility (odds ratio [OR]: 48.6) and sepsis (OR: 20.6) greatly increased the risk for ABE/BE, but TSB levels correlated poorly with the presence or absence of ABE or BE in these patients. The OR for ABO incompatibility with anemia (1.8) was not statistically significant. Low admission weight (OR: 0.83 per 100 g) increased the risk for BE, especially when other risk factors were present. The threshold TSB level that identified 90% of infants with ABE/BE was 25.4 mg/dL when neurotoxicity risk factors were present. In contrast, neurotoxicity was first observed at a TSB level of >31.5 mg/dL in 111 infants without risk factors.
conclusionsNewborns without risk factors for neurotoxicity have a higher tolerance for hyperbilirubinemia than recognized in management guidelines. The risk for BE in hemolytic disease varies with etiology. The great variation in response to TSB indicates that biological factors other than TSB values are important in the pathogenesis of BE.
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