Evidence map›Paper›PMID 21911339›Full record

ArticleEuropean heart journal2012

Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events.

Lasse Jespersen, Anders Hvelplund, Steen Z Abildstrøm, Frants Pedersen, Søren Galatius, Jan K Madsen, Erik Jørgensen, Henning Kelbæk, Eva Prescott

5 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in European heart journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 453 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
453citing papers in PubMed, 7 pooled it
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02910154 nacompletedstarted 2016, after this paper: background citation

Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower Cohort

Ran2016Enrolled62Registered outcomes9Posted comparisons0ConditionsAngina Pectoris, Coronary Microvascular DiseaseArmsdiet, Medication (with statin and ACE-inhibition), training
PMID 19878986PMID 19231324PMID 19351944PMID 19433695PMID 19712795PMID 19833255PMID 20220183PMID 20579539PMID 21105792PMID 21450596PMID 21861950PMID 22007073other papers from this trial
Open the trial in the graph
NCT02602600 phase4completednot on this mapstarted 2015, after this paper: background citation

Effect of Glucagon-like Peptide-1 Stimulation on Coronary Microvascular Dysfunction in Women With Angina Pectoris and no Obstructive Stenosis of Major Coronary Vessels

TypeinterventionalSponsorEva PrescottRan2015 to 2017Enrolled33ConditionsMicrovascular AnginaArmsLiraglutide
NCT04674449 narecruitingnot on this mapstarted 2020, after this paper: background citation

International Study of Coronary Microvascular Angina (iCorMicA): a Randomised, Controlled, Multicentre Trial and Registry

TypeinterventionalSponsorNHS Greater Glasgow and ClydeRan2020 to 2030Enrolled1,500ConditionsMicrovascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)ArmsDisclosure of IDP results, IDP performed but results not disclosed
NCT05714241 recruitingnot on this mapstarted 2022, after this paper: background citation

BIOmarkers and PLAtelet Function Assessment in Myocardial Ischemia and Non Obstructive Coronary Arteries Study: The BIOplatINO Study

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2022 to 2027Enrolled200ConditionsIschemia With no Obstructive Coronary Artery DiseaseArmsData extraction, Blood sampling, Clinical Follow-up
NCT06306066 completednot on this mapstarted 2015, after this paper: background citation

Coronary Microvascular Dysfunction in Chronic Coronary Syndrome - Invasive Assessment With Thermo-dilution Technique in the LAD and Biobanking in an All-comer Population

TypeobservationalSponsorKarolinska InstitutetRan2015 to 2022Enrolled505ConditionsCoronary Artery Disease, Microvascular Angina, Coronary Microvascular Dysfunction
3 · Its place in the literature

Who cites it

453 citing papers in PubMed, 7 syntheses or guidelines pooled it, 923 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The Diagnostic Value of ECG Characteristics for Vasospastic and Microvascular Angina: A Systematic Review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Utility ofCirculation. Cardiovascular imaging · 2025
    Trial
  12. Trial
  13. Trial
  14. Women's heart and echocardiography.Journal of cardiovascular imaging · 2026
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

393 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lasse JespersenDepartment of Cardiology, Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark. lasjes@gmail.com
Anders Hvelplund
Steen Z Abildstrøm
Frants Pedersen
Søren Galatius
Jan K Madsen
Erik Jørgensen
Henning Kelbæk
Eva Prescott
Bispebjerg Hospital · DKGentofte Hospital · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPatients with chest pain and no obstructive coronary artery disease (CAD) are considered at low risk for cardiovascular events but evidence supporting this is scarce. We investigated the prognostic implications of stable angina pectoris in relation to the presence and degree of CAD with no obstructive CAD in focus. METHODS AND

resultsWe identified 11 223 patients referred for coronary angiography (CAG) in 1998-2009 with stable angina pectoris as indication and 5705 participants from the Copenhagen City Heart Study for comparison. Main outcome measures were major adverse cardiovascular events (MACE), defined as cardiovascular death, myocardial infarction, stroke or heart failure, and all-cause mortality. Significantly more women (65%) than men (32%) had no obstructive CAD (P< 0.001). In Cox's models adjusted for age, body mass index, diabetes, smoking, and use of lipid-lowering or antihypertensive medication, hazard ratios (HRs) associated with no obstructive CAD were similar in men and women. In the pooled analysis, the risk of MACE increased with increasing degrees of CAD with multivariable-adjusted HRs of 1.52 (95% confidence interval, 1.27-1.83) for patients with normal coronary arteries and 1.85 (1.51-2.28) for patients with diffuse non-obstructive CAD compared with the reference population. For all-cause mortality, normal coronary arteries and diffuse non-obstructive CAD were associated with HRs of 1.29 (1.07-1.56) and 1.52 (1.24-1.88), respectively.

conclusionPatients with stable angina and normal coronary arteries or diffuse non-obstructive CAD have elevated risks of MACE and all-cause mortality compared with a reference population without ischaemic heart disease.

Indexed as

AdultAgedAngina, StableCoronary AngiographyCoronary Artery DiseaseDenmarkEpidemiologic MethodsFemaleHeart FailureHumansMaleMiddle AgedMyocardial IschemiaPrognosisStrokeYoung Adult

Identifiers

PMID21911339
OpenAlexW2110123637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.