Melanoma brain metastases: is it time to reassess the bias?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

22 citing papers in PubMed.

1. Long-Term Survival of Patients With Melanoma With Active Brain Metastases Treated With Pembrolizumab on a Phase II Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019
   Trial
2. Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial.The Lancet. Oncology · 2016
   Trial
3. Patterns of brain metastases response to immunotherapy with pembrolizumab.Journal of neuro-oncology · 2024
   Article
4. Efficacy of Large Use of Combined Hypofractionated Radiotherapy in a Cohort of Anti-PD-1 Monotherapy-Treated Melanoma Patients.Cancers · 2022
   Article
5. Emerging Studies of Melanoma Brain Metastasis.Current oncology reports · 2022
   Review
6. Oncolytic Virotherapy for Melanoma Brain Metastases, a Potential New Treatment Paradigm?Brain sciences · 2021
   Review
7. Survival Benefits of Anti-PD-1 Therapy in Combination With Radiotherapy in Chinese Melanoma Patients With Brain Metastasis.Frontiers in oncology · 2021
   Article
8. Stereotactic radiosurgery combined with targeted/ immunotherapy in patients with melanoma brain metastasis.Radiation oncology (London, England) · 2020
   Article
9. Pembrolizumab for non-small cell lung cancer with central nervous system metastases: A two-case report.Thoracic cancer · 2019
   Article
10. Robotic Stereotactic Radiosurgery in Melanoma Patients with Brain Metastases under Simultaneous Anti-PD-1 Treatment.International journal of molecular sciences · 2018
    Article
11. CD271 determines migratory properties of melanoma cells.Scientific reports · 2017
    Article
12. The Treatment of Melanoma Brain Metastases.Current oncology reports · 2016
    Review
13. Melanoma Brain Metastasis: Mechanisms, Models, and Medicine.International journal of molecular sciences · 2016
    Review
14. Melanoma Brain Metastasis Pseudoprogression after Pembrolizumab Treatment.Cancer immunology research · 2016
    Article
15. Non-coding RNAs in cancer brain metastasis.Frontiers in bioscience (Scholar edition) · 2016
    Review
16. Systemic Immunotherapy for the Treatment of Brain Metastases.Frontiers in oncology · 2016
    Review
17. Clinical trials in melanoma patients with brain metastases.Pigment cell & melanoma research · 2015
    Article
18. Characterization of PD-L1 Expression and Associated T-cell Infiltrates in Metastatic Melanoma Samples from Variable Anatomic Sites.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015
    Article
19. PLEKHA5 as a Biomarker and Potential Mediator of Melanoma Brain Metastasis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015
    Article
20. Predictors and survival in patients with melanoma brain metastases.Medical oncology (Northwood, London, England) · 2013
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

9 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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