ArticleMicroscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada2011
Quantification of collagen organization and extracellular matrix factors within the healing ligament.
Article in Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Macroscopic comparison of open Metzenbaum and ultrasound-guided fasciotomy techniques for surgical treatment of the hindlimb proximal suspensory ligament desmopathy in horses: A cadaveric anatomical study.Veterinary surgery : VS · 2026Article
- Tendon gel using the film model method promotes ligament healing in rabbits.Archives of orthopaedic and trauma surgery · 2026Article
- Should We Accept the Epiligament Theory About the Differences in the Healing Potential of the Medial Collateral and the Anterior Cruciate Ligament?Biomedicines · 2025Article
- Tendon mechanobiology in the context of tendon biofabrication.Frontiers in bioengineering and biotechnology · 2025Review
- Article
- An in-vivo study of photobiomodulation using 403 nm and 649 nm diode lasers for molar tooth extraction wound healing in wistar rats.Odontology · 2022Article
- The novel epiligament theory: differences in healing failure between the medial collateral and anterior cruciate ligaments.Journal of experimental orthopaedics · 2022Review
- Molecular Portrait of an Athlete.Diagnostics (Basel, Switzerland) · 2021Review
- Anterior cruciate ligament reconstruction in a rabbit model using a silk-collagen scaffold modified by hydroxyapatite at both ends: a histological and biomechanical study.Journal of orthopaedic surgery and research · 2021Article
- Exosome-educated macrophages and exosomes differentially improve ligament healing.Stem cells (Dayton, Ohio) · 2021Article
- Microscopic Assessment of Healing and Effectiveness of a Foam-Based Peripheral Occlusion Device.ACS biomaterials science & engineering · 2020Article
- Review
- Extracellular Matrix Expression and Production in Fibroblast-Collagen Gels: Towards an In Vitro Model for Ligament Wound Healing.Annals of biomedical engineering · 2018Article
- A validated software application to measure fiber organization in soft tissue.Biomechanics and modeling in mechanobiology · 2016Article
- Effects of BMP-12-releasing sutures on Achilles tendon healing.Tissue engineering. Part A · 2015Article
- Immunohistochemical Expression of Collagens in the Skin of Horses Treated with Leukocyte-Poor Platelet-Rich Plasma.BioMed research international · 2015Article
- Interleukin-1 receptor antagonist modulates inflammation and scarring after ligament injury.Connective tissue research · 2014Article
- Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury.Osteoarthritis and cartilage · 2013Article
- The +1245g/t polymorphisms in the collagen type I alpha 1 (col1a1) gene in polish skiers with anterior cruciate ligament injury.Biology of sport · 2013Article
- Temporal healing in rat achilles tendon: ultrasound correlations.Annals of biomedical engineering · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Ligament healing of a grade III injury (i.e., a complete tear) involves a multifaceted chain of events that forms a neoligament, which is more scar-like in character than the native tissue. The remodeling process may last months or even years with the injured ligament never fully recovering pre-injury mechanical properties. With tissue engineering and regenerative medicine, understanding the normal healing process in ligament and quantifying it provide a basis to create and assess innovative treatments. Ligament fibroblasts produce a number of extracellular matrix (ECM) components, including collagen types I and III, decorin and fibromodulin. Using a combination of advanced histology, molecular biology, and nonlinear optical imaging approaches, the early ECM events during ligament healing have been better characterized and defined. First, the dynamic changes in ECM factors after injury are shown. Second, the factors associated with creeping substitution are identified. Finally, a method to quantify collagen organization is developed and used. Each ECM factor described herein as well as the temporal quantification of fiber organization helps elucidate the complexity of ligament healing.
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