ArticleBMC psychiatry2011
A pattern of cerebral perfusion anomalies between major depressive disorder and Hashimoto thyroiditis.
Article in BMC psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Igg-Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia.Journal of immunology research · 2020Article
- Depression, fatigue and neurocognitive deficits in chronic hepatitis C.Hepatology international · 2018Review
- Bipolar disorder and antithyroid antibodies: review and case series.International journal of bipolar disorders · 2016Article
- The Burden of Depressive and Bipolar Disorders in Celiac Disease.Clinical practice and epidemiology in mental health : CP & EMH · 2015Article
- Assessing regional cerebral blood flow in depression using 320-slice computed tomography.PloS one · 2014Article
- Psychiatric symptoms and quality of life in systemic sclerosis.Clinical practice and epidemiology in mental health : CP & EMH · 2012Article
- Schizophrenia: from epidemiology to rehabilitation.Clinical practice and epidemiology in mental health : CP & EMH · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to evaluate relationship between three different clinical conditions: Major Depressive Disorders (MDD), Hashimoto Thyroiditis (HT) and reduction in regional Cerebral Blood Flow (rCBF) in order to explore the possibility that patients with HT and MDD have specific pattern(s) of cerebral perfusion.
methods
designAnalysis of data derived from two separate data banks. SAMPLE: 54 subjects, 32 with HT (29 women, mean age 38.8 ± 13.9); 22 without HT (19 women, mean age 36.5 ± 12.25). ASSESSMENT: Psychiatric diagnosis was carried out by Simplified Composite International Diagnostic Interview (CIDIS) using DSM-IV categories; cerebral perfusion was measured by (99 m)Tc-ECD SPECT. Statistical analysis was done through logistic regression.
resultsMDD appears to be associated with left frontal hypoperfusion, left temporal hypoperfusion, diffuse hypoperfusion and parietal perfusion asymmetry. A statistically significant association between parietal perfusion asymmetry and MDD was found only in the HT group.
conclusionIn HT, MDD is characterized by a parietal flow asymmetry. However, the specificity of rCBF in MDD with HT should be confirmed in a control sample with consideration for other health conditions. Moreover, this should be investigated with a longitudinally designed study in order to determine a possible pathogenic cause. Future studies with a much larger sample size should clarify whether a particular perfusion pattern is associated with a specific course or symptom cluster of MDD.
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Registered trials
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