ArticleRespiratory research2011
Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheeze.
Article in Respiratory research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- A systematic review of predictive models for asthma development in children.BMC medical informatics and decision making · 2015Pooled it
- Clinical characteristics and prognostic factors influencing respiratory syncytial virus pneumonia in children with atopy: a retrospective cohort study.Translational pediatrics · 2026Article
- Systemic IL-10 and IFN-γ Levels in Respiratory Syncytial Virus- and Rhinovirus-Infected Bulgarian Children with Acute Bronchiolitis and Their Impact on Clinical Manifestation.Pathogens (Basel, Switzerland) · 2025Article
- Post-viral lung diseases: the microbiota as a key player.ERJ open research · 2025Review
- Age-dependent differences in type I interferon, IL-12 and pro-inflammatory cytokine production by porcine peripheral blood mononuclear cells in response to pseudorabies virus-infected cells.Frontiers in immunology · 2025Article
- Disease Severity and Cytokine Expression in the Rhinovirus-Induced First Wheezing Episode.Viruses · 2024Article
- Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children.World journal of pediatrics : WJP · 2024Review
- Association ofFrontiers in neuroscience · 2023Article
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- Age-dependent nasal immune responses in non-hospitalized bronchiolitis children.Frontiers in immunology · 2022Article
- Recurrent Wheeze Exacerbations Following Acute Bronchiolitis-A Machine Learning Approach.Frontiers in allergy · 2021Article
- Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population.Virology journal · 2019Article
- Polymorphisms in the promoter region of IL10 gene are associated with virus etiology of infant bronchiolitis.World journal of pediatrics : WJP · 2018Article
- The impact of respiratory viruses on lung health after preterm birth.European clinical respiratory journal · 2018Review
- The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood.Infectious diseases and therapy · 2017Review
- Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis.Medicine · 2017Observational
- Article
- Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE).BMC pulmonary medicine · 2015Observational
- The role of macrophage IL-10/innate IFN interplay during virus-induced asthma.Reviews in medical virology · 2015Review
- The CD4 T cell response to respiratory syncytial virus infection.Immunologic research · 2014Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants. Following RSV bronchiolitis, 50% of children develop post-bronchiolitis wheeze (PBW). Animal studies have suggested that interleukin (IL)-10 plays a critical role in the pathogenesis of RSV bronchiolitis and subsequent airway hyperresponsiveness. Previously, we showed that ex vivo monocyte IL-10 production is a predictor of PBW. Additionally, heterozygosity of the single-nucleotide polymorphism (SNP) rs1800872 in the IL10 promoter region was associated with protection against RSV bronchiolitis.
methodsThis study aimed to determine the in vivo role of IL-10 in RSV pathogenesis and recurrent wheeze in a new cohort of 235 infants hospitalized for RSV bronchiolitis. IL-10 levels in nasopharyngeal aspirates (NPAs) were measured at the time of hospitalization and the IL10 SNP rs1800872 genotype was determined. Follow-up data were available for 185 children (79%).
resultsLocal IL-10 levels during RSV infection turned out to be higher in infants that later developed physician diagnosed PBW as compared to infants without PBW in the first year after RSV infection (958 vs 692 pg/ml, p = 0.02). The IL10 promoter SNP rs1800872 was not associated with IL-10 concentration in NPAs.
conclusionThe relationship between high local IL-10 levels during the initial RSV infection and physician diagnosed PBW provides further evidence of the importance of the IL-10 response during RSV bronchiolitis.
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