Evidence map›Paper›PMID 21910579›Full record

ReviewExpert review of gastroenterology & hepatology2011

New molecular insights into inflammatory bowel disease-induced diarrhea.

Yueming Tang, Christopher B Forsyth, Ali Keshavarzian

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of gastroenterology & hepatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Frontiers in pharmacology · 2025
    Article
  3. Intestinal Epithelial Cell Brush Border Membrane Cl:HCOInternational journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
  6. Frontiers in immunology · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Epithelial transport in inflammatory bowel diseases.Inflammatory bowel diseases · 2014
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yueming TangDepartment of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA. yueming_tang@rush.edu
Christopher B Forsyth
Ali Keshavarzian
Rush University Medical Center · US

Funding

Brain-gut circadian rhythm interactions in alcohol-induced gut leakinessR01AA020216 · NIAAA · RUSH UNIVERSITY MEDICAL CENTER · PI KESHAVARZIAN, ALI, TUREK, FRED W · 2010 to 2014
$3.0M
Systems Biology Approach to Identifying Biomarkers for Alcoholic Liver DiseaseRC2AA019405 · NIAAA · RUSH UNIVERSITY MEDICAL CENTER · PI GILLEVET, PATRICK MARTIN, KESHAVARZIAN, ALI · 2009 to 2010
$2.0M
microRNA, Intestinal Permeability and Alcoholic Liver DiseaseR21AA018729 · NIAAA · RUSH UNIVERSITY MEDICAL CENTER · PI TANG, YUEMING · 2010 to 2011
$405k
NIAAA NIH HHS AA019405NIAAA NIH HHS AA020216NIAAA NIH HHS AA18729NIAAA NIH HHS R01 AA020216NIAAA NIH HHS R21 AA018729NIAAA NIH HHS RC2 AA019405
6 · The paper itself

Abstract

Diarrhea is one of the common symptoms that significantly affects quality of life in patients with inflammatory bowel disease (IBD). The clinical manifestation of diarrhea is mainly dependant on the type of IBD and the location, extent and severity of intestinal inflammation. Understanding the pathophysiologic mechanisms of diarrhea in patients with IBD will be beneficial to developing effective treatments for IBD-associated diarrhea. In recent years, modern molecular techniques have been used intensively to dissect the role of the intestinal microbiota, epithelial barrier and the host immune system in the mechanisms of IBD-induced diarrhea. These studies have significantly advanced our knowledge of the mechanisms of IBD-induced diarrhea. In this article, we focus on the new and critical molecular insights into the contributions of the intestinal microbiota, epithelial tight junctions, proinflammatory cytokines and microRNA as potential mechanisms underlying to IBD-induced diarrhea.

Indexed as

CytokinesDiarrheaHumansImmune SystemInflammatory Bowel DiseasesIntestinesMicroRNAsTight JunctionsCytokinesMicroRNAs

Identifiers

PMID21910579
PMCPMC3227675
OpenAlexW2074426682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.