ArticleApoptosis : an international journal on programmed cell death2011
Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis.
Article in Apoptosis : an international journal on programmed cell death, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 41 citations in OpenAlex.
- The interplay between vitamin D3 and Nrf2 signaling: mechanistic insights and therapeutic potentials.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Article
- Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management.Drug delivery · 2025Review
- A review of silicosis and other silica-related diseases in the engineered stone countertop processing industry.Journal of occupational medicine and toxicology (London, England) · 2025Review
- Biomarkers of genotoxic damage in pulmonary alveolar macrophages: a review.Archives of toxicology · 2025Review
- A comprehensive retrospect on the current perspectives and future prospects of pneumoconiosis.Frontiers in public health · 2024Review
- Genetic polymorphisms and their effects on the severity of silicosis in workers exposed to silica in Brazil.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022Article
- The Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis.International journal of molecular sciences · 2021Review
- Atractylenolide III alleviates the apoptosis through inhibition of autophagy by the mTOR-dependent pathway in alveolar macrophages of human silicosis.Molecular and cellular biochemistry · 2021Article
- Macrophage Autophagy and Silicosis: Current Perspective and Latest Insights.International journal of molecular sciences · 2021Review
- Article
- Renal involvement in a silicosis patient - case report and literature review.Renal failure · 2019Review
- Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy.Theranostics · 2019Article
- Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner.Toxicology research · 2018Article
- BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis.Cell death & disease · 2017Article
- Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes.International journal of nanomedicine · 2017Article
- Cell-Based Therapy for Silicosis.Stem cells international · 2016Review
- cFLIP overexpression in T cells in thymoma-associated myasthenia gravis.Annals of clinical and translational neurology · 2015Article
- Lipopolysaccharides may aggravate apoptosis through accumulation of autophagosomes in alveolar macrophages of human silicosis.Autophagy · 2015Article
- Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis.Journal of clinical biochemistry and nutrition · 2015Article
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
In vitro and in vivo studies have demonstrated that lung cell apoptosis is associated with lung fibrosis; however the relationship between apoptosis of alveolar macrophages (AMs) and human silicosis has not been addressed. In the present study, AM apoptosis was determined in whole-lung lavage fluid from 48 male silicosis patients, 13 male observers, and 13 male healthy volunteers. The relationships between apoptosis index (AI) and silica exposure history, soluble Fas (sFas)/membrane-bound Fas (mFas), and caspase-3/caspase-8 were analyzed. AI, mFas, and caspase-3 were significantly higher in lung lavage fluids from silicosis patients than those of observers or healthy volunteers, but the level of sFas demonstrated a decreasing trend. AI was related to silica exposure, upregulation of mFas, and activation of caspase-3 and -8, as well as influenced by smoking status after adjusting for confounding factors. These results indicate that AM apoptosis could be used as a potential biomarker for human silicosis, and the Fas/FasL pathway may regulate this process. The present data from human lung lavage samples may help to understand the mechanism of silicosis and in turn lead to strategies for preventing or treating this disease.
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