SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2012
Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 132 citations in OpenAlex.
- Microsphere System Coloading Type I Collagen and Dexamethasone Sodium Phosphate for Osteoarthritis Therapy.ACS pharmacology & translational science · 2026Article
- Synergistic Effects of Calcium Phosphate Biomaterials Combined with Honey on Osteochondral Regeneration: A Qualitative Study in an Animal Model.Bioengineering (Basel, Switzerland) · 2026Article
- Multimodal mechanisms of platelet-rich plasma in bone defect repair: Angiogenesis, inflammation modulation, and metabolic regulation.Regenerative therapy · 2025Review
- 3D printed osteochondral scaffolds: design strategies, present applications and future perspectives.Frontiers in bioengineering and biotechnology · 2024Review
- Advances with Platelet-Rich Plasma for Bone Healing.Biologics : targets & therapy · 2024Review
- Manufacture of Bilayered Composite Hydrogels with Strong, Elastic, and Tough Properties for Osteochondral Repair Applications.Biomimetics (Basel, Switzerland) · 2023Article
- A Review of Biomimetic and Biodegradable Magnetic Scaffolds for Bone Tissue Engineering and Oncology.International journal of molecular sciences · 2023Review
- Insights into osteoarthritis development from single-cell RNA sequencing of subchondral bone.RMD open · 2022Article
- miRNA induced 3D bioprinted-heterotypic osteochondral interface.Biofabrication · 2022Article
- The advances in nanomedicine for bone and cartilage repair.Journal of nanobiotechnology · 2022Review
- Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing.Pharmaceutics · 2021Review
- The effectiveness of platelet-rich plasma gel on full-thickness cartilage defect repair in a rabbit model.Bone & joint research · 2021Article
- Histological Comparison of Nanocomposite Multilayer Biomimetic Scaffold, A Chondral Scaffold, and Microfracture Technique to Repair Experimental Osteochondral Defects in Rats.The Eurasian journal of medicine · 2020Article
- In Vitro Fabrication of Hybrid Bone/Cartilage Complex Using Mouse Induced Pluripotent Stem Cells.International journal of molecular sciences · 2020Article
- Age-Related Regeneration of Osteochondral and Tibial Defects by a Fibrin-Based ConstructFrontiers in bioengineering and biotechnology · 2020Article
- Toward zonally tailored scaffolds for osteochondral differentiation of synovial mesenchymal stem cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Clinical and radiographic outcomes of chitosan-glycerol phosphate/blood implant are similar with hyaluronic acid-based cell-free scaffold in the treatment of focal osteochondral lesions of the knee joint.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Progress in three-dimensional printing with growth factors.Journal of controlled release : official journal of the Controlled Release Society · 2019Review
- Should orthopedic surgeons consider reducing the negative effects of Outerbridge grade 2 patellofemoral chondral lesion on early postoperative recovery during anterior cruciate ligament reconstruction.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Article
- A Comparative Study of the Effects of Different Decellularization Methods and Genipin-Cross-Linking on the Properties of Tracheal Matrices.Tissue engineering and regenerative medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOsteochondral defects (i.e., defects which affect both the articular cartilage and underlying subchondral bone) are often associated with mechanical instability of the joint and therefore with the risk of inducing osteoarthritic degenerative changes. This review addresses the current surgical treatments and most promising tissue engineering approaches for articular cartilage and subchondral bone regeneration.
methodsThe capability to repair osteochondral or bone defects remains a challenging goal for surgeons and researchers. So far, most clinical approaches have been shown to have limited capacity to treat severe lesions. Current surgical repair strategies vary according to the nature and size of the lesion and the preference of the operating surgeon. Tissue engineering has emerged as a promising alternative strategy that essentially develops viable substitutes capable of repairing or regenerating the functions of damaged tissue.
resultsAn overview of novel and most promising osteochondroconductive scaffolds, osteochondroinductive signals, osteochondrogenic precursor cells, and scaffold fixation approaches are presented addressing advantages, drawbacks, and future prospectives for osteochondral regenerative medicine.
conclusionTissue engineering has emerged as an excellent approach for the repair and regeneration of damaged tissue, with the potential to circumvent all the limitations of autologous and allogeneic tissue repair. LEVEL OF EVIDENCE: Systematic review, Level III.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.