ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2011
Data mining for response shift patterns in multiple sclerosis patients using recursive partitioning tree analysis.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Detection of response shift in health-related quality of life studies: a systematic review.Health and quality of life outcomes · 2022Pooled it
- Using the random forest method to detect a response shift in the quality of life of multiple sclerosis patients: a cohort study.BMC medical research methodology · 2013Trial
- Developing Interim Outcome Measures for Multi-Arm Multistage Clinical Trials in Multiple Sclerosis.Neurology · 2026Article
- The importance of patient-reported outcomes: A call for their integration in the routine care of patients with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Review
- Quality of life should be the primary outcome for disease modifying therapy trials in MS-No.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- The value of patient-reported outcome measures for multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Quality of life of transplanted children and their parents: a cross-sectional study.Orphanet journal of rare diseases · 2021Article
- The minimal perceived change: a formal model of the responder definition according to the patient's meaning of change for patient-reported outcome data analysis and interpretation.BMC medical research methodology · 2021Article
- Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study.International journal of environmental research and public health · 2020Article
- How peoples' ratings of dental implant treatment change over time?Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Advancing quality-of-life research by deepening our understanding of response shift: a unifying theory of appraisal.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Using classification and regression tree modelling to investigate response shift patterns in dentine hypersensitivity.BMC medical research methodology · 2017Article
- Introduction to special section on response shift at the item level.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- How recent health-related life events affected my perspective on quality-of-life research.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Identifying reprioritization response shift in a stroke caregiver population: a comparison of missing data methods.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Observational
- Method variation in the impact of missing data on response shift detection.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Guidelines for secondary analysis in search of response shift.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2013Article
- Measuring the quality of life in patients with multiple sclerosis in clinical practice: a necessary challenge.Multiple sclerosis international · 2013Article
- Response shift in patients with multiple sclerosis: an application of three statistical techniques.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
aimsTo examine evidence of QOL response shift in patients with multiple sclerosis (MS) using recursive partitioning tree analysis (RPART) technique.
methodsSUBJECTS: MS patients from the NARCOMS registry assessed an average of 6 times at a median interval of 6 months. OUTCOMES: SF-12v2 Physical & Mental Component Scores (PCS, MCS). Covariates: Patient-determined disease steps, Performance Scales, and symptomatic therapies. RPART trees were fitted separately by 3 disease-trajectory groups: (1) relapsing (n = 1,582); (2) stable (n = 787); and (3) progressive (n = 639). The resulting trees were interpreted by identifying salient terminal nodes that showed the unexpected quantitative patterns of contrasting MCS and PCS scores (e.g., PCS deteriorates but MCS is stable or improves), using a minimally important difference of at least 5 points on the SF-12v2. Qualitative indicators of response shift were different thresholds (recalibration), content (reconceptualization), and order (reprioritization) of disability domains in predicting PCS change by group.
resultsOverall, 20% of patients demonstrated response shift quantitatively, with 10% in the "progressive" cohort, 8% in the "relapsing" cohort, and 2% in the "stable" cohort. RPART trees differed qualitatively across disease-trajectory groups in patterns suggestive of recalibration, reprioritization, and reconceptualization. Disability subscales, but not symptom management, distinguished homogenous groups.
conclusionsPCS and MCS change scores are obfuscated by response shifts. The contingent true scores for PCS change scores are not comparable across patient groups.
Indexed as
Identifiers
21909992What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.