ArticleEuropean journal of applied physiology2012
Ghrelin and PYY levels in adolescents with severe obesity: effects of weight loss induced by long-term exercise training and modified food habits.
Article in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Energetic adaptations to weight loss in children and adolescents with obesity: a systematic review and meta-analysis.International journal of obesity (2005) · 2026Pooled it
- Systematic Review: Does Exercise Training Influence Ghrelin Levels?International journal of molecular sciences · 2025Pooled it
- Ghrelin Response to Acute and Chronic Exercise: Insights and Implications from a Systematic Review of the Literature.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Does exercise during a ketogenic diet effectively alter appetite sensation, appetite-regulating hormones, and body composition?Experimental biology and medicine (Maywood, N.J.) · 2022Trial
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- The role of PYY in improving insulin resistance.Frontiers in endocrinology · 2026Review
- Peptide YY in Type 2 Diabetes: A Complementary Gut Hormone with Therapeutic Potential Beyond GLP-1.Nutrients · 2025Review
- Gut-derived appetite regulating hormones across the anorexia nervosa spectrum.Psychoneuroendocrinology · 2025Article
- Impact of Resistance and Endurance Training on Ghrelin and Plasma Leptin Levels in Overweight and Obese Subjects.International journal of molecular sciences · 2024Review
- Bone changes post-sleeve gastrectomy in relation to body mass and hormonal changes.European journal of endocrinology · 2023Observational
- Article
- Bone Metabolism in Adolescents Undergoing Bariatric Surgery.The Journal of clinical endocrinology and metabolism · 2021Review
- Appetite Control Might not Be Improved after Weight Loss in Adolescents with Obesity, Despite Non-Persistent Metabolic Syndrome.Nutrients · 2020Article
- Obstructive Sleep Apnea and Sleep Architecture in Adolescents With Severe Obesity: Effects of a 9-Month Lifestyle Modification Program Based on Regular Exercise and a Balanced Diet.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Attenuating the Biologic Drive for Weight Regain Following Weight Loss: Must What Goes Down Always Go Back Up?Nutrients · 2017Review
- Reduced neural response to food cues following exercise is accompanied by decreased energy intake in obese adolescents.International journal of obesity (2005) · 2016Article
- Metabolic surgery: action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature.Best practice & research. Clinical gastroenterology · 2014Review
- Short-term aerobic exercise training increases postprandial pancreatic polypeptide but not peptide YY concentrations in obese individuals.International journal of obesity (2005) · 2014Article
- Anorexia nervosa, obesity and bone metabolism.Pediatric endocrinology reviews : PER · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated (a) changes in ghrelin and peptide YY (PYY) concentrations during a weight reduction programme and (b) baseline ghrelin and PYY levels as predictors of weight loss in 32 severely obese adolescents (BMI z score = 4.1). Subjects spent an academic year in an institution for childhood obesity. Fasting ghrelin and PYY, leptin, insulin levels and insulin resistance were measured at baseline (month 0) and during the programme (months 3, 6, 9). In addition, 15 normal-weight teenagers served as reference for the baseline assessments. At baseline, obese teenagers had lower ghrelin and PYY concentrations than normal-weight adolescents (P < 0.05). Moreover, they showed significantly higher leptin, insulin levels and homeostasis model assessment (HOMA) (P < 0.0001). During the lifestyle modification, there was a significant decrease in body weight among obese teenagers, associated with an increase in ghrelin (apparent from month 6; P < 0.05), a decrease in leptin (from month 3; P < 0.05) and a decrease in insulin and HOMA (from month 3; P < 0.0001), without any significant change in PYY. Anthropometrical changes were correlated neither with baseline ghrelin levels nor with changes in ghrelin and PYY after the lifestyle modification. However, higher baseline PYY tended to correlate with greater anthropometrical changes (P < 0.1). In adolescents with severe obesity, a long-term combination of supervised aerobic exercises and a balanced diet led to weight reduction and increased ghrelin concentrations, without any change in PYY concentrations. Moreover, baseline PYY concentrations might be considered as predictors of weight loss.
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