ArticleBehavior genetics2012
Mecp2 truncation in male mice promotes affiliative social behavior.
Article in Behavior genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Selective Deletion of Methyl CpG Binding Protein 2 from Parvalbumin Interneurons in the Auditory Cortex Delays the Onset of Maternal Retrieval in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Vitamin D modulates cortical transcriptome and behavioral phenotypes in an Mecp2 heterozygous Rett syndrome mouse model.Neurobiology of disease · 2022Article
- Social Evolution in African Mole-Rats - A Comparative Overview.Advances in experimental medicine and biology · 2021Article
- Sex differences in Mecp2-mutant Rett syndrome model mice and the impact of cellular mosaicism in phenotype development.Brain research · 2020Review
- The role of MeCP2 in learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering.Human molecular genetics · 2017Article
- Family Wide Molecular Adaptations to Underground Life in African Mole-Rats Revealed by Phylogenomic Analysis.Molecular biology and evolution · 2015Article
- Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Applying the ethoexperimental approach to neurodevelopmental syndrome research reveals exaggerated defensive behavior in Mecp2 mutant mice.Physiology & behavior · 2015Article
- Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice.Molecular metabolism · 2015Article
- Inactivation of the catalytic phosphatase domain of PTPRT/RPTPρ increases social interaction in mice.Autism research : official journal of the International Society for Autism Research · 2015Article
- Article
- Mild expression differences of MECP2 influencing aggressive social behavior.EMBO molecular medicine · 2014Article
- Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas.Autism research : official journal of the International Society for Autism Research · 2014Article
- Vascular dysfunction in a mouse model of Rett syndrome and effects of curcumin treatment.PloS one · 2013Article
- Oxytocin receptor and Mecp2 308/Y knockout mice exhibit altered expression of autism-related social behaviors.Physiology & behavior · 2012Review
- Preclinical research in Rett syndrome: setting the foundation for translational success.Disease models & mechanisms · 2012Review
- Beyond WidespreadAutism-open access · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Mouse models of Rett syndrome, with targeted mutations in the Mecp2 gene, show a high degree of phenotypic consistency with the clinical syndrome. In addition to severe and age-specific regression in motor and cognitive abilities, a variety of studies have demonstrated that Mecp2 mutant mice display impaired social behavior. Conversely, other studies indicate complex enhancements of social behavior in Mecp2 mutant mice. Since social behavior is a complicated accumulation of constructs, we performed a series of classic and refined social behavior tasks and revealed a relatively consistent pattern of enhanced pro-social behavior in hypomorphic Mecp2 (308/Y) mutant mice. Analyses of repetitive motor acts, and cognitive stereotypy did not reveal any profound differences due to genotype. Taken together, these results suggest that the mutations associated with Rett syndrome are not necessarily associated with autism-relevant social impairment in mice. However, this gene may be a valuable candidate for revealing basic mechanisms of affiliative behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.