ArticlePloS one2011
TrpA1 regulates thermal nociception in Drosophila.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 198 citations in OpenAlex.
- Zoledronic acid produces analgesia by inhibiting the transient receptor potential vanilloid 1 (TRPV1) channel.Pain reports · 2026Article
- Sodium valproate and gabapentin reduce the seizure-like behavior induced by pentylenetetrazol and mechanical stress in Drosophila melanogaster: sex influence on behavioral responses.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Comparative Transcriptome Analysis of the Abdominal Ganglion Reveals Molecular Networks and Key Genes Underlying Thermal Tolerance in Red Swamp Crayfish (Animals : an open access journal from MDPI · 2026Article
- Genome-wide identification and temperature-responsive expression profiling of TRP gene family in red swamp crayfish (Procambarus clarkii).BMC genomics · 2026Article
- TRPA1 for Butterfly Eyespot Formation.International journal of molecular sciences · 2026Article
- Understanding animal temperature sensation: from molecular thermosensors to physiological impacts.Science China. Life sciences · 2026Review
- Article
- ILP4 and InR regulate paclitaxel-induced hypersensitivity differently inMolecular biology of the cell · 2026Article
- Ascending nociceptive pathways drive rapid escape and sustained avoidance in adultbioRxiv : the preprint server for biology · 2025Article
- Article
- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Exploiting TRP channel diversity in insects: a pathway to next-generation pest management.Archives of toxicology · 2025Review
- Nociception inCold Spring Harbor protocols · 2025Article
- Beyond the heat shock pathway: Heat stress responses in Drosophila development.Developmental biology · 2025Review
- Multiple mechanisms of action for an extremely painful venom.Current biology : CB · 2025Article
- Cross-modal sensory compensation increases mosquito attraction to humans.Science advances · 2025Article
- A nociceptor-specific RNAi screen inPeerJ · 2025Article
- Revealing the Bioactivities ofToxins · 2024Article
- Vitamin B5 is a context-dependent dietary regulator of nociception.G3 (Bethesda, Md.) · 2024Article
- Multiple mechanisms of action of an extremely painful venom.bioRxiv : the preprint server for biology · 2024Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger. To prevent damage the systems that detect noxious stimuli are therefore under strict evolutionary pressure. We developed a high-throughput behavioral method to identify genes contributing to thermal nociception in the fruit fly and have reported a large-scale screen that identified the Ca²⁺ channel straightjacket (stj) as a conserved regulator of thermal nociception. Here we present the minimal anatomical and neuronal requirements for Drosophila to avoid noxious heat in our novel behavioral paradigm. Bioinformatics analysis of our whole genome data set revealed 23 genes implicated in Ca²⁺ signaling that are required for noxious heat avoidance. One of these genes, the conserved thermoreceptor TrpA1, was confirmed as a bona fide "pain" gene in both adult and larval fly nociception paradigms. The nociceptive function of TrpA1 required expression within the Drosophila nervous system, specifically within nociceptive multi-dendritic (MD) sensory neurons. Therefore, our analysis identifies the channel TRPA1 as a conserved regulator of nociception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.