ArticlePloS one2011
Variations in shape-sensitive restriction points mirror differences in the regeneration capacities of avian and mammalian ears.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear.Frontiers in cellular neuroscience · 2022Article
- YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- EGF and a GSK3 Inhibitor Deplete Junctional E-cadherin and Stimulate Proliferation in the Mature Mammalian Ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Some Ototoxic Drugs Destroy Cochlear Support Cells Before Damaging Sensory Hair Cells.Neurotoxicity research · 2020Article
- Junctional E-cadherin/p120-catenin Is Correlated with the Absence of Supporting Cells to Hair Cells Conversion in Postnatal Mice Cochleae.Frontiers in molecular neuroscience · 2018Article
- Development and regeneration of vestibular hair cells in mammals.Seminars in cell & developmental biology · 2017Review
- Regeneration of hair cells in the mammalian vestibular system.Frontiers of medicine · 2016Review
- Live imaging the phagocytic activity of inner ear supporting cells in response to hair cell death.Cell death and differentiation · 2015Article
- Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle.Frontiers in cellular neuroscience · 2015Article
- Responses to cell loss become restricted as the supporting cells in mammalian vestibular organs grow thick junctional actin bands that develop high stability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Lead roles for supporting actors: critical functions of inner ear supporting cells.Hearing research · 2013Review
- Inner ear supporting cells: rethinking the silent majority.Seminars in cell & developmental biology · 2013Review
- A historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?".Hearing research · 2013Review
- In vivo proliferative regeneration of balance hair cells in newborn mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
When inner ear hair cells die, humans and other mammals experience permanent hearing and balance deficits, but non-mammalian vertebrates quickly recover these senses after epithelial supporting cells give rise to replacement hair cells. A postnatal decline in cellular plasticity appears to limit regeneration in mammalian balance organs, where declining proliferation responses are correlated with decreased spreading of supporting cells on artificial and native substrates. By culturing balance epithelia on substrates that differed in flexibility, we assessed spreading effects independent of age, showing a strong correlation between shape change and supporting cell proliferation. Then we made excision wounds in utricles cultured from young and old chickens and mice and compared quantified levels of spreading and proliferation. In utricles from young mice, and both young and old chickens, wounds re-epithelialized in <24 hours, while those in utricles from mature mice took three times longer. More cells changed shape in the fastest healing wounds, which accounted for some differences in the levels of proliferation, but inter-species and age-related differences in shape-sensitive restriction points, i.e., the cellular thresholds for shape changes that promote S-phase, were evident and may be particularly influential in the responses to hair cell losses in vivo.
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