Evidence map›Paper›PMID 21909344›Full record

ReviewCurrent opinion in virology2011

The role of dendritic cells in viral persistence.

Cherie T Ng, Brian M Sullivan, Michael B A Oldstone

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cherie T NgViral-Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Brian M Sullivan
Michael B A Oldstone
Scripps Research Institute · US

Funding

PATHOGENESIS OF PERSISTENT VIRAL INFECTIONR01AI009484 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI OLDSTONE, MICHAEL B · 1985 to 2016
$7.2M
BLOOD SYSTEMS IN COAGULATION AND VESSEL DISEASET32HL007195 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUF, WOLFRAM · 1985 to 2011
$5.1M
ARENAVIRUS RECEPTOR--STRUCTURE/FUNCTION STUDIESR01AI045927 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI OLDSTONE, MICHAEL B · 2000 to 2010
$3.6M
Virology of the Central Nervous SystemT32NS041219 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI ELDER, JOHN H · 2001 to 2010
$2.4M
In Vivo Analysis of T lymphocytes in the Persistently Infected CNSR01AI070967 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI OLDSTONE, MICHAEL B · 2007 to 2011
$2.3M
PATHOGENESIS OF PERSISTENT VIRAL INFECTIONR37AI009484 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI OLDSTONE, MICHAEL B · 1988 to 1997
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NHLBI NIH HHS 5 T32 HL007195-34NHLBI NIH HHS T32 HL007195NIAID NIH HHS AI09484NIAID NIH HHS AI45927NIAID NIH HHS AI70967NIAID NIH HHS R01 AI009484NIAID NIH HHS R01 AI045927NIAID NIH HHS R01 AI070967NINDS NIH HHS 2 T32NS041219-11NINDS NIH HHS T32 NS041219
6 · The paper itself

Abstract

Viruses must modulate or suppress their host's immune system in order to persist. In this review, we discuss the means in which the lympocytic choriomenengitis virus targets and infects an essential component of the immune system, the dendritic cell, essential to bridging the innate and adaptive immune response. Infection of these cells results in pleiotropic effects that serve to deregulate the host immune response.

Indexed as

AnimalsDendritic CellsHumansLymphocytic ChoriomeningitisLymphocytic choriomeningitis virus

Identifiers

PMID21909344
PMCPMC3167161
OpenAlexW1972230545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.