ReviewInternational journal of environmental research and public health2011
Insights from epidemiology into dichloromethane and cancer risk.
Review in International journal of environmental research and public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Multi-Layered Microneedles Loaded with Microspheres.AAPS PharmSciTech · 2025Article
- Leukemia Incidence by Occupation and Industry: A Cohort Study of 2.3 Million Workers from Ontario, Canada.International journal of environmental research and public health · 2024Article
- Applying a Green Solvent with Microwave, Ultrasound, and Soxhlet Extraction Techniques to Quantify the Slip AdditivePolymers · 2023Article
- Predicting the total PAHs concentrations in sediments from selected congeners using a multiple linear relationship.Scientific reports · 2022Article
- Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California.International journal of hygiene and environmental health · 2017Article
- Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France.Environmental health : a global access science source · 2017Article
- Experimental outgassing of toxic chemicals to simulate the characteristics of hazards tainting globally shipped products.PloS one · 2017Article
- Human health effects of dichloromethane: key findings and scientific issues.Environmental health perspectives · 2015Review
- Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan.International journal of clinical and experimental pathology · 2014Article
- Central nervous system tumors: a single center pathology review of 34,140 cases over 60 years.BMC clinical pathology · 2013Article
- Article
- Occupational exposure to chlorinated solvents and risks of glioma and meningioma in adults.Occupational and environmental medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dichloromethane (methylene chloride) is a widely used chlorinated solvent. We review the available epidemiology studies (five cohort studies, 13 case-control studies, including seven of hematopoietic cancers), focusing on specific cancer sites. There was little indication of an increased risk of lung cancer in the cohort studies (standardized mortality ratios ranging from 0.46 to 1.21). These cohorts are relatively small, and variable effects (e.g., point estimates ranging from 0.5 to 2.0) were seen for the rarer forms of cancers such as brain cancer and specific hematopoietic cancers. Three large population-based case-control studies of incident non-Hodgkin lymphoma in Europe and the United States observed odds ratios between 1.5 and 2.2 with dichloromethane exposure (ever exposed or highest category of exposure), with higher risk seen in specific subsets of disease. More limited indications of associations with brain cancer, breast cancer, and liver and biliary cancer were also seen in this collection of studies. Existing cohort studies, given their size and uneven exposure information, are unlikely to resolve questions of cancer risks and dichloromethane exposure. More promising approaches are population-based case-control studies of incident disease, and the combination of data from such studies, with robust exposure assessments that include detailed occupational information and exposure assignment based on industry-wide surveys or direct exposure measurements.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.