ArticlePLoS biology2011
A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
106 citing papers in PubMed, 239 citations in OpenAlex.
- Bioinformatic Analysis and Tissue-Specific Expression of Clock Genes andAnimals : an open access journal from MDPI · 2026Article
- Convergent latitudinal erosion of circadian systems in a rapidly diversifying order of fishes.PLoS genetics · 2026Article
- Non-visual opsins and their role in circadian photoentrainment.Eye and vision (London, England) · 2026Review
- Article
- A simple and rapid shaking-based assay to genotype live, early developmental stage zebrafish embryos.Laboratory animals · 2025Article
- Light-Induced Transcription in Zebrafish Targets Mitochondrial Function and Heme Metabolism.Antioxidants (Basel, Switzerland) · 2025Article
- A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms.iScience · 2025Article
- Evolution of the Nonvisual and Visual Opsin Gene Repertoire in Ray-Finned Fishes.Genome biology and evolution · 2025Article
- Is there direct photoentrainment in the goldfish liver? Wavelength-dependent regulation of clock genes and investigation of the opsin 7 family.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Postprandial Sleep in Short-Sleeping Mexican Cavefish.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024Article
- Sporadic feeding regulates robust food entrainable circadian clocks in blind cavefish.iScience · 2024Article
- Light wavelength modulates search behavior performance in zebrafish.Scientific reports · 2024Article
- Ontogeny and social context regulate the circadian activity patterns of Lake Malawi cichlids.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- The interplay between sleep and ecophysiology, behaviour and responses to environmental change in fish.The Journal of experimental biology · 2024Review
- 3D spheroid culturing of Astyanax mexicanus liver-derived cell lines recapitulates distinct transcriptomic and metabolic states of in vivo tissue environment.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Circadian rhythm and surface activity in soil-dwelling caecilians (Amphibia: Gymnophiona).Scientific reports · 2024Article
- Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution.Antioxidants (Basel, Switzerland) · 2024Review
- Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish.PLoS genetics · 2024Article
- All Light, Everywhere? Photoreceptors at Nonconventional Sites.Physiology (Bethesda, Md.) · 2024Review
- Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish retains a food-entrainable clock that oscillates with an infradian period. Importantly, however, this clock is not regulated by light. This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as essential upstream elements of the peripheral clock light input pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.