Evidence map›Paper›PMID 21909110›Full record

SynthesisNature genetics2011

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

Louise V Wain, Germaine C Verwoert, Paul F O'Reilly, Gang Shi, Toby Johnson, Andrew D Johnson, Murielle Bochud, Kenneth M Rice, Peter Henneman, Albert V Smith and 222 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 275 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 22 pooled it
23.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

275 citing papers in PubMed, 22 syntheses or guidelines pooled it, 443 citations in OpenAlex.

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  19. Arterial Stiffness and Decline in Kidney Function.Clinical journal of the American Society of Nephrology : CJASN · 2015
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215 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

232 authors at 20 institutions in 17 countries.

Louise V WainDepartment of Health Sciences, University of Leicester, Leicester, UK.
Germaine C Verwoert
Paul F O'Reilly
Gang Shi
Toby Johnson
Andrew D Johnson
Murielle Bochud
Kenneth M Rice
Peter Henneman
Albert V Smith
Georg B Ehret
Najaf Amin
Martin G Larson
Vincent Mooser
David Hadley
Marcus Dörr
Joshua C Bis
Thor Aspelund
Tõnu Esko
A Cecile J W Janssens
Jing Hua Zhao
Simon Heath
Maris Laan
Jingyuan Fu
Giorgio Pistis
Jian'an Luan
Pankaj Arora
Gavin Lucas
Nicola Pirastu
Irene Pichler
Anne U Jackson
Rebecca J Webster
Feng Zhang
John F Peden
Helena Schmidt
Toshiko Tanaka
Harry Campbell
Wilmar Igl
Yuri Milaneschi
Jouke-Jan Hottenga
Veronique Vitart
Daniel I Chasman
Stella Trompet
Jennifer L Bragg-Gresham
Behrooz Z Alizadeh
John C Chambers
Xiuqing Guo
Terho Lehtimäki
Brigitte Kühnel
Lorna M Lopez
Ozren Polašek
Mladen Boban
Christopher P Nelson
Alanna C Morrison
Vasyl Pihur
Santhi K Ganesh
Albert Hofman
Suman Kundu
Francesco U S Mattace-Raso
Fernando Rivadeneira
Eric J G Sijbrands
Andre G Uitterlinden
Shih-Jen Hwang
Ramachandran S Vasan
Thomas J Wang
Sven Bergmann
Peter Vollenweider
Gérard Waeber
Jaana Laitinen
Anneli Pouta
Paavo Zitting
Wendy L McArdle
Heyo K Kroemer
Uwe Völker
Henry Völzke
Nicole L Glazer
Kent D Taylor
Tamara B Harris
Helene Alavere
Toomas Haller
Aime Keis
Mari-Liis Tammesoo
Yurii Aulchenko
Inês Barroso
Kay-Tee Khaw
Pilar Galan
Serge Hercberg
Mark Lathrop
Susana Eyheramendy
Elin Org
Siim Sõber
Xiaowen Lu
Ilja M Nolte
Brenda W Penninx
Tanguy Corre
Corrado Masciullo
Cinzia Sala
Leif Groop
Benjamin F Voight
Olle Melander
Christopher J O'Donnell
Veikko Salomaa
Adamo Pio d'Adamo
Antonella Fabretto
Flavio Faletra
Sheila Ulivi
Fabiola M Del Greco
Maurizio Facheris
Francis S Collins
Richard N Bergman
John P Beilby
Joseph Hung
A William Musk
Massimo Mangino
So-Youn Shin
Nicole Soranzo
Hugh Watkins
Anuj Goel
Anders Hamsten
Pierre Gider
Marisa Loitfelder
Marion Zeginigg
Dena Hernandez
Samer S Najjar
Pau Navarro
Sarah H Wild
Anna Maria Corsi
Andrew Singleton
Eco J C de Geus
Gonneke Willemsen
Alex N Parker
Lynda M Rose
Brendan Buckley
David Stott
Marco Orru
Manuela Uda
LifeLines Cohort Study
Melanie M van der Klauw
Weihua Zhang
Xinzhong Li
James Scott
Yii-Der Ida Chen
Gregory L Burke
Mika Kähönen
Jorma Viikari
Angela Döring
Thomas Meitinger
Gail Davies
John M Starr
Valur Emilsson
Andrew Plump
Jan H Lindeman
Peter A C 't Hoen
Inke R König
EchoGen consortium
Janine F Felix
Robert Clarke
Jemma C Hopewell
Halit Ongen
Monique Breteler
Stéphanie Debette
Anita L Destefano
Myriam Fornage
AortaGen Consortium
Gary F Mitchell
CHARGE Consortium Heart Failure Working Group
Nicholas L Smith
KidneyGen consortium
Hilma Holm
Kari Stefansson
Gudmar Thorleifsson
Unnur Thorsteinsdottir
CKDGen consortium
Cardiogenics consortium
CardioGram
Nilesh J Samani
Michael Preuss
Igor Rudan
Caroline Hayward
Ian J Deary
H-Erich Wichmann
Olli T Raitakari
Walter Palmas
Jaspal S Kooner
Ronald P Stolk
J Wouter Jukema
Alan F Wright
Dorret I Boomsma
Stefania Bandinelli
Ulf B Gyllensten
James F Wilson
Luigi Ferrucci
Reinhold Schmidt
Martin Farrall
Tim D Spector
Lyle J Palmer
Jaakko Tuomilehto
Arne Pfeufer
Paolo Gasparini
David Siscovick
David Altshuler
Ruth J F Loos
Daniela Toniolo
Harold Snieder
Christian Gieger
Pierre Meneton
Nicholas J Wareham
Ben A Oostra
Andres Metspalu
Lenore Launer
Rainer Rettig
David P Strachan
Jacques S Beckmann
Jacqueline C M Witteman
Jeanette Erdmann
Ko Willems van Dijk
Eric Boerwinkle
Michael Boehnke
Paul M Ridker
Marjo-Riitta Jarvelin
Aravinda Chakravarti
Goncalo R Abecasis
Vilmundur Gudnason
Christopher Newton-Cheh
Daniel Levy
Patricia B Munroe
Bruce M Psaty
Mark J Caulfield
Dabeeru C Rao
Martin D Tobin
Paul Elliott
Cornelia M van Duijn
Erasmus MC · NLUniversity of Tartu · EEUniversity of Edinburgh · GBUniversity Medical Center Groningen · NLLeiden University Medical Center · NLNational Institute on Aging · USHelmholtz Zentrum München · DEKing's College London · GBMedical University of Graz · ATUniversity of Leicester · GBUniversity of Michigan · USUniversity of Washington · USCentre for Human Genetics · GBdeCODE Genetics (Iceland) · ISEurac Research · ITImperial College London · GBIRCCS Materno Infantile Burlo Garofolo · ITMRC Epidemiology Unit · GBUniversität Greifswald · DEWestern General Hospital · GB

Funding

Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Genomic Epidemiology of Cardiovascular DiseaseZIAHL006002 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI O'DONNELL, CHRISTOPHER · 2009 to 2015
$8.0M
GENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2M
Whole Genome Association for Early Coronary Artery Disease and Related PhenotypesR01HL087647 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2006 to 2008
$4.6M
Brain aging and cardiovascular risk factors and diseaseZIAAG007480 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2011 to 2025
$2.7M
The InChianti StudyZIAAG001050 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$2.1M
HISPANIC SECONDARY STROKE PREVENTION INITIATIVER01MD009164 · NIMHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN · 2014 to 2018
$1.9M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1991 to 2000
$1.6M
COMMUNITY AND COHORT SURVEILLANCE PROGRAMS-N01HC55015N01HC055015 · HC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI CHAMBLESS, LLOYD E · 1985 to 2006
$1.1M
Genetic determinants of cardiac repolarizationK23HL080025 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEWTON-CHEH, CHRISTOPHER HOLMES · 2005 to 2009
$797k
Biotechnology and Biological Sciences Research Council BB/F019394/1Chief Scientist Office CZB/4/505Chief Scientist Office CZB/4/710Chief Scientist Office ETM/55Intramural NIH HHS Z01 HG000024Medical Research Council G0401527Medical Research Council G0601966Medical Research Council G0700704Medical Research Council G0700931Medical Research Council G0701863Medical Research Council G0801056Medical Research Council G0902313Medical Research Council G1000143Medical Research Council G9521010Medical Research Council MC_PC_U127561128Medical Research Council MC_PC_U127592696Medical Research Council MC_U106179471Medical Research Council MC_U106188470Medical Research Council MC_U127561128Medical Research Council MC_U127592696Medical Research Council MC_U137686857NHLBI NIH HHS K23 HL080025NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC095159NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL105756NHLBI NIH HHS U10 HL054512NIA NIH HHS N01 AG012109Wellcome Trust 090532
6 · The paper itself

Abstract

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.

Indexed as

Genome-Wide Association StudyArteriesBlood PressureCase-Control StudiesFollow-Up StudiesGenetic LociHumansHypertensionLinkage DisequilibriumPolymorphism, Single Nucleotide

Identifiers

PMID21909110
PMCPMC3445021
OpenAlexW2102622802

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.