ArticleNature structural & molecular biology2011
Competition between ADAR and RNAi pathways for an extensive class of RNA targets.
Article in Nature structural & molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 81 citations in OpenAlex.
- On the origin, evolution, and maintenance of RNA editing.Nucleic acids research · 2025Review
- A low-abundance class of Dicer-dependent siRNAs produced from a variety of features inGenome research · 2024Article
- Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing.Science (New York, N.Y.) · 2024Article
- ADAR3 modulates neuronal differentiation and regulates mRNA stability and translation.Nucleic acids research · 2024Article
- ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia.PLoS biology · 2023Article
- ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations.RNA (New York, N.Y.) · 2022Review
- An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans.Developmental cell · 2021Article
- RESIC: A Tool for Comprehensive Adenosine to Inosine RNA Editing Site Identification and Classification.Frontiers in genetics · 2021Article
- Processing ofRNA (New York, N.Y.) · 2020Article
- mRNA Editing, Processing and Quality Control inGenetics · 2020Review
- Todos Santos small RNA symposium.RNA biology · 2019Article
- Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing.Cell reports · 2019Article
- Mapping the dsRNA World.Cold Spring Harbor perspectives in biology · 2019Review
- Article
- Dual-layer transposon repression in heads ofRNA (New York, N.Y.) · 2018Article
- A rADAR defense against RNAi.Genes & development · 2018Article
- Article
- RNA Editing and Retrotransposons in Neurology.Frontiers in molecular neuroscience · 2018Review
- Base-pairing probability in the microRNA stem region affects the binding and editing specificity of human A-to-I editing enzymes ADAR1-p110 and ADAR2.RNA biology · 2018Article
- Use/disuse paradigms are ubiquitous concepts in characterizing the process of inheritance.RNA biology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adenosine deaminases that act on RNAs (ADARs) interact with double-stranded RNAs, deaminating adenosines to inosines. Previous studies of Caenorhabditis elegans indicated an antagonistic interaction between ADAR and RNAi machineries, with ADAR defects suppressed upon additional knockout of RNAi. This suggests a pool of common RNA substrates capable of engaging both pathways. To define and characterize such substrates, we examined small RNA and mRNA populations of ADAR mutants and identified a distinct set of loci from which RNAi-dependent short RNAs are markedly upregulated. At these same loci, we observed populations of multiply edited transcripts, supporting a specific role for ADARs in preventing access to the RNAi pathway for an extensive population of dsRNAs. Characterization of these loci revealed a substantial overlap with noncoding and intergenic regions, suggesting that the landscape of ADAR targets may extend beyond previously annotated classes of transcripts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.