ArticleSchizophrenia bulletin2012
Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders.
Article in Schizophrenia bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Childhood Trauma and Neurocognition in Adults With Psychotic Disorders: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2019Pooled it
- Childhood trauma and hippocampal-dependent memory across the psychosis spectrum: a systematic review and meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.Social psychiatry and psychiatric epidemiology · 2023Article
- Environmental Risk Factors and Cognitive Outcomes in Psychosis: Pre-, Perinatal, and Early Life Adversity.Current topics in behavioral neurosciences · 2023Review
- Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder.Frontiers in psychiatry · 2020Article
- Childhood Trauma in Schizophrenia: Current Findings and Research Perspectives.Frontiers in neuroscience · 2019Review
- Sensorimotor gating deficits in "two-hit" models of schizophrenia risk factors.Schizophrenia research · 2018Review
- Reliability and validity of the Chinese version of the Childhood Trauma Questionnaire-Short Form for inpatients with schizophrenia.PloS one · 2018Article
- Trauma and the psychosis spectrum: A review of symptom specificity and explanatory mechanisms.Clinical psychology review · 2016Review
- Cognitive Impairment in Schizophrenia: Interplay of BDNF and Childhood Trauma? A Review of Literature.The Psychiatric quarterly · 2016Review
- A history of childhood trauma is associated with slower improvement rates: Findings from a one-year follow-up study of patients with a first-episode psychosis.BMC psychiatry · 2016Article
- The Association Between Breastfeeding Exposure and Duration, Neuropsychological Deficits, and Psychopathic Personality Traits in Offspring: The Moderating Role of 5HTTLPR.The Psychiatric quarterly · 2016Article
- Perinatal Risks and Childhood Premorbid Indicators of Later Psychosis: Next Steps for Early Psychosocial Interventions.Schizophrenia bulletin · 2015Review
- Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders.Clinical epigenetics · 2015Review
- A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation.Frontiers in psychiatry · 2014Review
- Recent advances in understanding schizophrenia.F1000prime reports · 2014Review
- Gene-environment interactions in severe mental illness.Frontiers in psychiatry · 2014Review
- The long-term impact of early adversity on late-life psychiatric disorders.Current psychiatry reports · 2013Review
- Patterns of childhood adverse events are associated with clinical characteristics of bipolar disorder.BMC psychiatry · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe functional polymorphism in the promoter region of the SLC6A4/5-HTT serotonin transporter gene (5-HTTLPR) has been linked to altered stress response. Carriers of the short (s-) allele have increased negative psychological reactions and stress hormone release compared with carriers of the long (l-) allele, interacting with severe life events including childhood trauma. High stress levels are associated with cognitive impairments in a variety of clinical and experimental studies. Patients with psychotic disorders are characterized both by more childhood traumatic events and abnormal stress responses and by significant but highly variable cognitive dysfunction. We hypothesize that 5-HTTLPR variations and long-term effects of childhood trauma interact and contribute to some of the variation in cognitive dysfunction seen in patients with psychotic disorders.
methodsPatients with psychotic disorders (schizophrenia and affective spectrums) were recruited from a catchment area-based treatment organization. History of childhood abuse was obtained by the Childhood Trauma Questionnaire. Cognitive function was assessed through a comprehensive, standardized neuropsychological test battery. 5-HTTLPR genotypes were analyzed using standard polymerase chain reaction.
resultsWe observed a significant interaction between 5-HTTLPR variants and childhood trauma across cognitive domains; here, homozygotic s-carriers exposed to high levels of childhood trauma (physical neglect and abuse) had significantly poorer cognitive functioning than all other groups.
conclusionsOur results need replication but underline the importance of investigating childhood trauma and its interaction with genetic markers when studying cognitive dysfunction in patients with psychotic disorders.
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