ArticleGenome research2011
Phyloepigenomic comparison of great apes reveals a correlation between somatic and germline methylation states.
Article in Genome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Towards molecular evolutionary epigenomics with an expanded nucleotide code involving methylated bases.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- An Analysis of Methylome Evolution in Primates.Molecular biology and evolution · 2021Article
- Microbial control of host gene regulation and the evolution of host-microbiome interactions in primates.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Intraspecific and interspecific investigations of skeletal DNA methylation and femur morphology in primates.American journal of physical anthropology · 2020Article
- A comparison of gene expression and DNA methylation patterns across tissues and species.Genome research · 2020Article
- Assessment of DNA Methylation Patterns in the Bone and Cartilage of a Nonhuman Primate Model of Osteoarthritis.Cartilage · 2019Article
- Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.Genome research · 2018Article
- Of Men and Mice: Modeling the Fragile X Syndrome.Frontiers in molecular neuroscience · 2018Article
- Species-Specific 5 mC and 5 hmC Genomic Landscapes Indicate Epigenetic Contribution to Human Brain Evolution.Frontiers in molecular neuroscience · 2018Article
- DNA methylation patterns of behavior-related gene promoter regions dissect the gray wolf from domestic dog breeds.Molecular genetics and genomics : MGG · 2017Article
- DNA Methylation: Insights into Human Evolution.PLoS genetics · 2015Review
- The interplay between DNA methylation and sequence divergence in recent human evolution.Nucleic acids research · 2015Article
- A diverse epigenetic landscape at human exons with implication for expression.Nucleic acids research · 2015Article
- Genomics and Evolution in Traditional Medicinal Plants: Road to a Healthier Life.Evolutionary bioinformatics online · 2015Review
- Epigenetics and evolution.Integrative and comparative biology · 2014Review
- Article
- Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases.Genome medicine · 2014Article
- Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes.Genome biology · 2013Article
- Dynamics of DNA methylation in recent human and great ape evolution.PLoS genetics · 2013Article
- Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We have determined methylation state differences in the epigenomes of uncultured cells purified from human, chimpanzee, and orangutan, using digestion with a methylation-sensitive enzyme, deep sequencing, and computational analysis of the sequence data. The methylomes show a high degree of conservation, but the methylation states of ~10% of CpG island-like regions differ significantly between human and chimp. The differences are not associated with changes in CG content and recapitulate the known phylogenetic relationship of the three species, indicating that they are stably maintained within each species. Inferences about the relationship between somatic and germline methylation states can be made by an analysis of CG decay, derived from methylation and sequence data. This indicates that somatic methylation states are highly related to germline states and that the methylation differences between human and chimp have occurred in the germline. These results provide evidence for epigenetic changes that occur in the germline and distinguish closely related species and suggest that germline epigenetic states might constrain somatic states.
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Registered trials
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