ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- PPARs in Clinical Experimental Medicine after 35 Years of Worldwide Scientific Investigations and Medical Experiments.Biomolecules · 2024Review
- Nutrients: Signal 4 in T cell immunity.The Journal of experimental medicine · 2024Article
- Physiological Convergence and Antagonism Between GR and PPARγ in Inflammation and Metabolism.Advances in experimental medicine and biology · 2022Review
- The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders.International journal of molecular sciences · 2021Review
- Metabolic coordination of T cell quiescence and activation.Nature reviews. Immunology · 2020Review
- Sex-specific regulation of immune responses by PPARs.Experimental & molecular medicine · 2017Review
- Peroxisome proliferator-activated receptor γ agonist suppresses mast cell maturation and induces apoptosis.Molecular medicine reports · 2017Article
- Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology.Brain : a journal of neurology · 2017Article
- Nutrient and Metabolic Sensing in T Cell Responses.Frontiers in immunology · 2017Review
- Review
- Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells.Nature communications · 2016Article
- Sex-Based Selectivity of PPARγ Regulation in Th1, Th2, and Th17 Differentiation.International journal of molecular sciences · 2016Article
- Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen.Scientific reports · 2016Article
- Protective effects of pioglitazone against immunoglobulin deposition on heart of streptozotocin-induced diabetic rats.Journal of endocrinological investigation · 2014Article
- Autoimmunity in 2012.Clinical reviews in allergy & immunology · 2013Review
- Metabolic control of the Treg/Th17 axis.Immunological reviews · 2013Review
- PPARγ Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?PPAR research · 2013Article
- mTOR, metabolism, and the regulation of T-cell differentiation and function.Immunological reviews · 2012Review
- Autoimmunity in 2011.Clinical reviews in allergy & immunology · 2012Review
- The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases.Molecules and cells · 2012Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ) was shown to play an immunoregulatory role in many immune-related cell types, and activation of PPARγ was reported to be an effective therapeutic approach in murine and human autoimmune disease. However, despite an association between lymphopenia and autoimmunity, there has been no study on the role of T cell PPARγ in lymphopenia-associated autoimmunity. In the present studies, we examined the role of PPARγ in CD4(+) T cells in two murine models of lymphopenia-associated autoimmunity. Surprisingly, we found that PPARγ expression in CD4(+) CD25(-) T cells (T effector cells [Teffs]) is actually required for development of autoimmunity under lymphopenic conditions. Mechanistically, the inability of PPARγ-deficient (T-PPAR) Teffs to mediate lymphopenic autoimmunity is associated with a significant decrease in accumulation of Teffs in the spleen, lymph nodes, and tissues after adoptive transfer. This abnormal accumulation of T-PPAR Teffs was associated with defects in both in vivo proliferation and survival. Additionally, T-PPAR Teffs demonstrated decreased cytokine production in inflammatory sites and decreased expression of the homing receptor α4β7. Finally, these abnormalities in T-PPAR Teff function were not elicited by lymphopenia alone but also required the additional activation involved in the mediation of autoimmunity. Thus, in contrast to its documented immunosuppressive role, we identified an unexpected function for PPARγ in Teffs: a role in Teff proliferation and survival in lymphopenia-associated autoimmunity. These findings highlight both the multifunctional role of PPARγ in T cells and the complexity of PPARγ as a potential therapeutic target in autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.