Evidence map›Paper›PMID 21908727›Full record

ArticleThe Journal of infectious diseases2011

Lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthrax.

Anne E Boyer, Conrad P Quinn, Cari A Beesley, Maribel Gallegos-Candela, Chung K Marston, Li X Cronin, Renato C Lins, Robyn A Stoddard, Han Li, Jarad Schiffer and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  5. Review of anthrax: A disease of farm animals.Journal of advanced veterinary and animal research · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Anne E BoyerCenters for Disease Control and Prevention, Atlanta, GA 30341, USA. aboyer@cdc.gov
Conrad P Quinn
Cari A Beesley
Maribel Gallegos-Candela
Chung K Marston
Li X Cronin
Renato C Lins
Robyn A Stoddard
Han Li
Jarad Schiffer
M Jahangir Hossain
Apurba Chakraborty
Mahmudur Rahman
Stephen P Luby
Wun-Ju Shieh
Sherif Zaki
John R Barr
Alex R Hoffmaster
International Centre for Diarrhoeal Disease Research · BDAnalytical Services · USInstitute of Epidemiology, Disease Control and Research · BDThe Centers · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), anti-protective antigen (anti-PA) immunoglobulin G (IgG), and anthrax lethal toxin neutralization activity (TNA) levels were determined in acute and convalescent serum of 26 case patients with suspected cutaneous anthrax from the first and largest of these outbreaks. LF (0.005-1.264 ng/mL) was detected in acute serum from 18 of 26 individuals. Anti-PA IgG and TNA were detected in sera from the same 18 individuals and ranged from 10.0 to 679.5 μg/mL and 27 to 593 units, respectively. Seroconversion to serum anti-PA and TNA was found only in case patients with measurable toxemia. This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses.

Indexed as

Disease OutbreaksAnimalsAnthraxAntibodies, BacterialAntibodies, NeutralizingAntigens, BacterialAntitoxinsBacterial ToxinsBangladeshHumansImmunoglobulin GSkin Diseases, Bacterialanthrax toxinAntibodies, BacterialAntibodies, NeutralizingAntigens, BacterialAntitoxinsBacterial ToxinsImmunoglobulin G

Identifiers

PMID21908727
PMCPMC3182309
OpenAlexW2168098000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.