ArticleJournal of bacteriology2011
Regulation of perR expression by iron and PerR in Campylobacter jejuni.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- PerR: A Peroxide Sensor Eliciting Metal Ion-dependent Regulation in Various Bacteria.Molecular biotechnology · 2025Review
- Impacts ofJournal of bacteriology · 2025Article
- Aerotolerancy ofPathogens (Basel, Switzerland) · 2024Review
- Pleiotropic cellular responses underlying antibiotic tolerance inFrontiers in microbiology · 2024Article
- Development of Fluoroquinolone Resistance through Antibiotic Tolerance in Campylobacter jejuni.Microbiology spectrum · 2022Article
- XRE family transcriptional regulator XtrSs modulates Streptococcus suis fitness under hydrogen peroxide stress.Archives of microbiology · 2022Article
- CosR Regulation ofMicroorganisms · 2021Article
- Transducer-Like Protein inFrontiers in microbiology · 2018Article
- A Mutator Phenotype Promoting the Emergence of Spontaneous Oxidative Stress-Resistant Mutants in Campylobacter jejuni.Applied and environmental microbiology · 2017Article
- Article
- Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity.FEMS microbiology reviews · 2016Article
- Assessment of the influence of intrinsic environmental and geographical factors on the bacterial ecology of pit latrines.Microbial biotechnology · 2016Article
- Dual Repression of the Multidrug Efflux Pump CmeABC by CosR and CmeR in Campylobacter jejuni.Frontiers in microbiology · 2016Article
- Refined analysis of the Campylobacter jejuni iron-dependent/independent Fur- and PerR-transcriptomes.BMC genomics · 2015Article
- Non-selective regulation of peroxide and superoxide resistance genes by PerR in Campylobacter jejuni.Frontiers in microbiology · 2015Article
- Regulation of oxidative stress resistance in Campylobacter jejuni, a microaerophilic foodborne pathogen.Frontiers in microbiology · 2015Review
- The impairment of methylmenaquinol:fumarate reductase affects hydrogen peroxide susceptibility and accumulation in Campylobacter jejuni.MicrobiologyOpen · 2014Article
- Role of alkyl hydroperoxide reductase (AhpC) in the biofilm formation of Campylobacter jejuni.PloS one · 2014Article
- Mutational analysis of cj0183 Campylobacter jejuni promoter.Current microbiology · 2013Article
- Transcriptional regulation of the CmeABC multidrug efflux pump and the KatA catalase by CosR in Campylobacter jejuni.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter jejuni is a leading food-borne pathogen causing gastroenteritis in humans. Although OxyR is a widespread oxidative stress regulator in many Gram-negative bacteria, C. jejuni lacks OxyR and instead possesses the metalloregulator PerR. Despite the important role played by PerR in oxidative stress defense, little is known about the factors influencing perR expression in C. jejuni. In this study, a perR promoter-lacZ fusion assay demonstrated that iron significantly reduced the level of perR transcription, whereas other metal ions, such as copper, cobalt, manganese, and zinc, did not affect perR transcription. Notably, a perR mutation substantially increased the level of perR transcription and in trans complementation restored the transcriptional changes, suggesting perR is transcriptionally autoregulated in C. jejuni. In the perR mutant, iron did not repress perR transcription, indicating the iron dependence of perR expression results from perR autoregulation. Electrophoretic mobility shift assays showed that PerR binds to the perR promoter, and DNase I footprinting assays identified a PerR binding site overlapping the -35 region of the two perR promoters, further supporting perR autoregulation at the transcriptional level. Alignment of the PerR binding sequence in the perR promoter with the regulatory region of other PerR regulon genes of C. jejuni revealed a 16-bp consensus PerR binding sequence, which shares high similarities to the Bacillus subtilis PerR box. The results of this study demonstrated that PerR directly interacts with the perR promoter and regulates perR transcription and that perR autoregulation is responsible for the repression of perR transcription by iron in C. jejuni.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.