ArticleApplied and environmental microbiology2011
Salt stress-induced changes in the transcriptome, compatible solutes, and membrane lipids in the facultatively phototrophic bacterium Rhodobacter sphaeroides.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 82 citations in OpenAlex.
- Harnessing Rhodopseudomonas palustris strains for salt stress mitigation in Arabidopsis thaliana.BMC plant biology · 2026Article
- First Insights Into the Biological and Physical-Chemical Diversity of Various Salt Ponds of Trapani, Sicily.Environmental microbiology reports · 2025Article
- Identification of the principal neuropeptide MIP and its action pathway in larval settlement of the echiuran worm Urechis unicinctus.BMC genomics · 2024Article
- Effect of NaCl stress on exoproteome profiles ofFrontiers in microbiology · 2023Article
- Nitrogen Fixation Activity and Genome Analysis of a Moderately Haloalkaliphilic Anoxygenic Phototrophic BacteriumMicroorganisms · 2022Article
- Location and Conformational Ensemble of Menaquinone and Menaquinol, and Protein-Lipid Modulations in Archaeal Membranes.The journal of physical chemistry. B · 2021Article
- Multi-omics characterization of the osmotic stress resistance and protease activities of the halophilic bacteriumRSC advances · 2020Article
- Unveiling salinity effects on photo-bioelectrocatalysis through combination of bioinformatics and electrochemistry.Electrochimica acta · 2020Article
- Metabolic and proteomic alteration in phytohormone-producing endophytic Bacillus amyloliquefaciens RWL-1 during methanol utilization.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Beyond Chloride Brines: Variable Metabolomic Responses in the Anaerobic OrganismFrontiers in microbiology · 2018Article
- The Complete Genome and Physiological Analysis of the Microbialite-DwellingFrontiers in microbiology · 2018Article
- The Complete Genome and Physiological Analysis of the Eurythermal FirmicuteFrontiers in microbiology · 2018Article
- Overexpression of Zinc Finger Transcription Factor ZAT6 Enhances Salt Tolerance.Open life sciences · 2018Article
- Response of Methylocystis sp. Strain SC2 to Salt Stress: Physiology, Global Transcriptome, and Amino Acid Profiles.Applied and environmental microbiology · 2017Article
- Genomic, transcriptomic, and proteomic approaches towards understanding the molecular mechanisms of salt tolerance in Frankia strains isolated from Casuarina trees.BMC genomics · 2017Article
- Global Transcriptional Responses to Osmotic, Oxidative, and Imipenem Stress Conditions in Pseudomonas putida.Applied and environmental microbiology · 2017Article
- Bacterial Survival under Extreme UV Radiation: A Comparative Proteomics Study ofFrontiers in microbiology · 2017Article
- Characterization of the mechanism of prolonged adaptation to osmotic stress of Jeotgalibacillus malaysiensis via genome and transcriptome sequencing analyses.Scientific reports · 2016Article
- A comprehensive genomic, transcriptomic and proteomic analysis of a hyperosmotic stress sensitive α-proteobacterium.BMC microbiology · 2015Article
- Draft Genome Sequence of the Extremely Halophilic Bacterium Halomonas salina Strain CIFRI1, Isolated from the East Coast of India.Genome announcements · 2015Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Responses to NaCl stress were investigated in phototrophically grown Alphaproteobacterium Rhodobacter sphaeroides by transcriptome profiling, mutational analysis, and measurements of compatible solutes and membrane phospholipids. After exposure to salt stress, genes encoding two putative glycine betaine uptake systems, proVWX and betS, were highly upregulated. Mutational analysis revealed that BetS, not ProVWX, was the primary transporter of this compatible solute. Upon the addition of salt, exogenous glycine betaine was taken up rapidly, and maximal intracellular levels were reached within minutes. In contrast, synthesis of another important compatible solute in R. sphaeroides, trehalose, increased slowly following salt stress, reaching maximal levels only after several hours. This accumulation pattern was consistent with the more gradual increase in salt-induced transcription of the trehalose biosynthesis operon otsBA. Several genes encoding putative transcription factors were highly induced by salt stress. Multiple copies of one of these factors, crpO (RSP1275), whose product is a member of the cyclic AMP receptor protein/fumarate and nitrate reduction regulator (CRP/FNR) family, improved NaCl tolerance. When crpO was provided in multicopy, expression of genes for synthesis or transport of compatible solutes was unaltered, but the membrane phospholipid composition became biased toward that found in salt-stressed cells. Collectively, this study characterized transcriptional responses to salt stress, correlated changes in transcription with compatible solute accumulation rates, identified the main glycine betaine transporter and trehalose synthase, characterized salt-induced changes in phospholipid composition, and uncovered a transcription factor associated with changes in phospholipids. These findings set the stage for deciphering the salt stress-responsive regulatory network in R. sphaeroides.
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