ArticleApplied and environmental microbiology2011
Intergenic sequence comparison of Escherichia coli isolates reveals lifestyle adaptations but not host specificity.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Genomic diversity of diarrheagenic multidrug-resistant Escherichia coli across asymptomatic children and livestock in Nairobi, Kenya.PLOS global public health · 2026Article
- Comprehensive Analysis ofMicroorganisms · 2025Article
- The biological function of the type II toxin-antitoxin systemFrontiers in microbiology · 2024Article
- Genetic Determinants of Escherichia coli Survival in Beach Sand.Applied and environmental microbiology · 2023Article
- Whole-Genome Sequencing and Virulome Analysis of Escherichia coli Isolated from New Zealand Environments of Contrasting Observed Land Use.Applied and environmental microbiology · 2022Article
- A Broad Continuum of E. coli Traits in Nature Associated with the Trade-off Between Self-preservation and Nutritional Competence.Microbial ecology · 2022Article
- Biofilm Formation and Antimicrobial Susceptibility ofFrontiers in microbiology · 2022Article
- Niche Preference ofLife (Basel, Switzerland) · 2021Article
- Molecular epidemiology of blaAnnals of clinical microbiology and antimicrobials · 2021Article
- Selective survival ofApplied and environmental microbiology · 2021Article
- A One Health Perspective for Defining and DecipheringComparative medicine · 2021Review
- The utility of Escherichia coli as a contamination indicator for rural drinking water: Evidence from whole genome sequencing.PloS one · 2021Article
- Review
- The Locus of Heat Resistance Confers Resistance to Chlorine and Other Oxidizing Chemicals in Escherichia coli.Applied and environmental microbiology · 2020Article
- Article
- Acquisition and dissemination of cephalosporin-resistant E. coli in migratory birds sampled at an Alaska landfill as inferred through genomic analysis.Scientific reports · 2018Article
- Sieving through gut models of colonization resistance.Nature microbiology · 2018Review
- Whole-Genome Sequencing of Bacterial Pathogens: the Future of Nosocomial Outbreak Analysis.Clinical microbiology reviews · 2017Review
- Patchy promiscuity: machine learning applied to predict the host specificity ofMicrobial genomics · 2017Article
- Distribution of Diverse Escherichia coli between Cattle and Pasture.Microbes and environments · 2017Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Establishing the risk of human infection is one of the goals of public health. For bacterial pathogens, the virulence and zoonotic potential can often be related to their host source. Escherichia coli bacteria are common contaminants of water associated with human recreation and consumption, and many strains are pathogenic. In this study, we analyzed three promoter-containing intergenic regions from 284 diverse E. coli isolates in an attempt to identify molecular signatures associated with specific host types. Promoter sequences controlling production of curli fimbriae, flagella, and nutrient import yielded a phylogenetic tree with isolates clustered by established phylogenetic grouping (A, B1, B2, and D) but not by host source. Virulence genes were more prevalent in groups B2 and D isolates and in human isolates. Group B1 isolates, primarily from nonhuman sources, were the most genetically similar, indicating that they lacked molecular adaptations to specific host environments and were likely host generalists. Conversely, B2 isolates, primarily from human sources, displayed greater genetic distances and were more likely to be host adapted. In agreement with these hypotheses, prevalence of σ(S) activity and the rdar morphotype, phenotypes associated with environmental survival, were significantly higher in B1 isolates than in B2 isolates. Based on our findings, we speculate that E. coli host specificity is not defined by genome-wide sequence changes but, rather, by the presence or absence of specific genes and associated promoter elements. Furthermore, the requirements for colonization of the human gastrointestinal tract may lead to E. coli lifestyle changes along with selection for increased virulence.
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