Evidence map›Paper›PMID 21908411›Full record

ArticleAmerican journal of respiratory and critical care medicine2011

Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma.

Atul Gupta, Alies Sjoukes, David Richards, Winston Banya, Catherine Hawrylowicz, Andrew Bush, Sejal Saglani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 6 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 6 syntheses or guidelines pooled it, 327 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Vitamin D deficiency is associated with the severity of COPD: a systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease · 2015
    Pooled it
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  7. Trial
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  11. Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014
    Trial
  12. Article
  13. Review
  14. Article
  15. Article
  16. Impact of Vitamin D3 Supplementation on Symptom Severity & IgE in Persistent Allergic Rhinitis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Vitamin D and allergic diseases.Frontiers in immunology · 2024
    Review

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Atul GuptaDepartment of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK. atulgupta@doctors.org.uk
Alies Sjoukes
David Richards
Winston Banya
Catherine Hawrylowicz
Andrew Bush
Sejal Saglani
King's College London · GBAsthma UK · GBImperial College London · GBRoyal Brompton Hospital · GB

Funding

Department of HealthMedical Research Council G1000758Wellcome Trust 083586
6 · The paper itself

Abstract

rationaleLittle is known about vitamin D status and its effect on asthma pathophysiology in children with severe, therapy-resistant asthma (STRA).

objectivesRelationships between serum vitamin D, lung function, and pathology were investigated in pediatric STRA.

methodsSerum 25-hydroxyvitamin D [25(OH)D(3)] was measured in 86 children (mean age, 11.7 yr): 36 with STRA, 26 with moderate asthma (MA), and 24 without asthma (control subjects). Relationships between 25(OH)D(3), the asthma control test (ACT), spirometry, corticosteroid use, and exacerbations were assessed. Twenty-two of 36 children with STRA underwent fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy with assessment of airway inflammation and remodeling. MEASUREMENTS AND MAIN

results25(OH)D(3) levels (median [IQR]) were significantly lower in STRA (28 [22-38] nmol/L) than in MA (42.5 [29-63] nmol/L) and control subjects (56.5 [45-67] nmol/L) (P < 0.001). There was a positive relationship between 25(OH)D(3) levels and percent predicted FEV(1) (r = 0.4, P < 0.001) and FVC (r = 0.3, P = 0.002) in all subjects. 25(OH)D(3) levels were positively associated with ACT (r = 0.6, P < 0.001), and inversely associated with exacerbations (r = -0.6, P < 0.001) and inhaled steroid dose (r = -0.39, P = 0.001) in MA and STRA. Airway smooth muscle (ASM) mass, but not epithelial shedding or reticular basement membrane thickness, was inversely related to 25(OH)D(3) levels (r = -0.6, P = 0.008). There was a positive correlation between ASM mass and bronchodilator reversibility (r = 0.6, P = 0.009) and an inverse correlation between ASM mass and ACT (r = -0.7, P < 0.001).

conclusionsLower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function. The link between vitamin D, airway structure, and function suggests vitamin D supplementation may be useful in pediatric STRA.

Indexed as

Airway RemodelingAdolescentAsthmaCase-Control StudiesChildComorbidityFemaleHumansMaleProspective StudiesRespiratory Function TestsVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin D

Identifiers

PMID21908411
PMCPMC3471128
OpenAlexW1996282132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.