ArticleThe Journal of molecular diagnostics : JMD2011
Rapid high-resolution mapping of balanced chromosomal rearrangements on tiling CGH arrays.
Article in The Journal of molecular diagnostics : JMD, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Array comparative genomic hybridisation in haematological malignancies: A comprehensive review.African journal of laboratory medicine · 2026Review
- Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization.The Journal of molecular diagnostics : JMD · 2016Article
- Evolution of genetic techniques: past, present, and beyond.BioMed research international · 2015Review
- Human molecular cytogenetics: From cells to nucleotides.Genetics and molecular biology · 2014Review
- Characterization of a case of follicular lymphoma transformed into B-lymphoblastic leukemia.Molecular cytogenetics · 2013Article
- Value of oligonucleotide-based array comparative genomic hybridization for diagnosis of acute promyelocytic leukemia in a patient negative for t(15;17)(q24.1;q21.2)/promyelocytic leukemia-retinoic acid receptor, alpha by conventional cytogenetics and fluorescence in situ hybridization.Clinical lymphoma, myeloma & leukemia · 2013Article
- Genome Fusion Detection: a novel method to detect fusion genes from SNP-array data.Bioinformatics (Oxford, England) · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
The diagnosis and classification of many cancers depends in part on the identification of large-scale genomic aberrations such as chromosomal deletions, duplications, and balanced translocations. Array-based comparative genomic hybridization (array CGH) can detect chromosomal imbalances on a genome-wide scale but cannot reliably identify balanced chromosomal rearrangements. We describe a simple modification of array CGH that enables simultaneous identification of recurrent balanced rearrangements and genomic imbalances on the same microarray. Using custom tiling oligonucleotide arrays and gene-specific linear amplification primers, translocation CGH (tCGH) maps balanced rearrangements to ∼100-base resolution and facilitates the rapid cloning and sequencing of novel rearrangement breakpoints. As proof of principle, we used tCGH to characterize nine of the most common gene fusions in mature B-cell neoplasms and myeloid leukemias. Because tCGH can be performed in any CGH-capable laboratory and can screen for multiple recurrent translocations and genome-wide imbalances, it should be of broad utility in the diagnosis and classification of various types of lymphomas, leukemias, and solid tumors.
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