ReviewTrends in cell biology2011
Axon regeneration mechanisms: insights from C. elegans.
Review in Trends in cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The utilization of small non-mammals in traumatic brain injury research: A systematic review.CNS neuroscience & therapeutics · 2021Pooled it
- The conserved fibroblast growth factor receptor-based signaling is required for dendrite regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tubulin autoregulation factors SCAPER and TTC5 recruit γ-tubulin to non-centrosomal MTOCs for neuronal microtubule nucleation and axon regeneration.bioRxiv : the preprint server for biology · 2025Article
- Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration.PLoS genetics · 2024Article
- Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing.Skeletal muscle · 2022Article
- Keeping Neurons Young and Foxy: FoxOs Promote Neuronal Plasticity.Trends in genetics : TIG · 2018Review
- Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response.Cell death & disease · 2016Article
- Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans.F1000Research · 2016Review
- Neurodegeneration and microtubule dynamics: death by a thousand cuts.Frontiers in cellular neuroscience · 2015Review
- Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae.Neural development · 2014Article
- Axon injury and regeneration in the adult Drosophila.Scientific reports · 2014Article
- Axon regeneration in C. elegans.Current opinion in neurobiology · 2014Review
- Article
- S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Axon regeneration genes identified by RNAi screening in C. elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A fully automated microfluidic femtosecond laser axotomy platform for nerve regeneration studies in C. elegans.PloS one · 2014Article
- Signaling pathways that regulate axon regeneration.Neuroscience bulletin · 2013Review
- The DLK signalling pathway--a double-edged sword in neural development and regeneration.EMBO reports · 2013Review
- Design and implementation of in vivo imaging of neural injury responses in the adult Drosophila wing.Nature protocols · 2013Article
- Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration.Developmental cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Understanding the mechanisms of axon regeneration is of great importance to the development of therapeutic treatments for spinal cord injury or stroke. Axon regeneration has long been studied in diverse vertebrate and invertebrate models, but until recently had not been analyzed in the genetically tractable model organism Caenorhabditis elegans. The small size, simple neuroanatomy, and transparency of C. elegans allows single fluorescently labeled axons to be severed in live animals using laser microsurgery. Many neurons in C. elegans are capable of regenerative regrowth, and can in some cases re-establish functional connections. Large-scale genetic screens have begun to elucidate the genetic basis of axon regrowth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.