Trial reportThe Journal of pediatrics2012
Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension.
Trial report in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Inhaled nitric oxide in premature infants for preventing bronchopulmonary dysplasia: a meta-analysis.BMC pediatrics · 2023Pooled it
- Inhaled nitric oxide increases urinary nitric oxide metabolites and cyclic guanosine monophosphate in premature infants: relationship to pulmonary outcome.American journal of perinatology · 2015Trial
- Heme-NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Endothelial LAT1 (SLC7A5) Mediates S-Nitrosothiol Import and Modulates Respiratory Sequelae of Red Blood Cell Transfusion In Vivo.Thrombosis and haemostasis · 2024Article
- Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury.PloS one · 2022Article
- Nitrite in breast milk: roles in neonatal pathophysiology.Pediatric research · 2021Review
- Treatment-related biomarkers in pulmonary hypertension patients on oral therapies.Respiratory research · 2020Article
- The role of gasotransmitters in neonatal physiology.Nitric oxide : biology and chemistry · 2020Review
- A pilot study on the kinetics of metabolites and microvascular cutaneous effects of nitric oxide inhalation in healthy volunteers.PloS one · 2019Article
- Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites.Nitric oxide : biology and chemistry · 2018Article
- Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Sex-specific associations between cerebrovascular blood pressure autoregulation and cardiopulmonary injury in neonatal encephalopathy and therapeutic hypothermia.Pediatric research · 2017Observational
- Treatment-related biomarkers in pulmonary hypertension.American journal of respiratory cell and molecular biology · 2015Review
- Dietary intake and bio-activation of nitrite and nitrate in newborn infants.Pediatric research · 2015Review
- Nitrite and nitrate concentrations and metabolism in breast milk, infant formula, and parenteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2014Article
- Oxidative Stress and Therapeutic Development in Lung Diseases.Journal of pulmonary & respiratory medicine · 2014Article
- Nitrate reductase activity of bacteria in saliva of term and preterm infants.Nitric oxide : biology and chemistry · 2012Article
- Can nitric oxide-based therapy prevent bronchopulmonary dysplasia?Clinics in perinatology · 2012Review
- Perioperative anesthesiological management of patients with pulmonary hypertension.Anesthesiology research and practice · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo measure the circulating concentrations of nitric oxide (NO) adducts with NO bioactivity after inhaled NO (iNO) therapy in infants with pulmonary hypertension. STUDY
designIn this single center study, 5 sequential blood samples were collected from infants with pulmonary hypertension before, during, and after therapy with iNO (n = 17). Samples were collected from a control group of hospitalized infants without pulmonary hypertension (n = 16) and from healthy adults for comparison (n = 12).
resultsAfter beginning iNO (20 ppm) whole blood nitrite levels increased approximately two-fold within 2 hours (P<.01). Whole blood nitrate levels increased to 4-fold higher than baseline during treatment with 20 ppm iNO (P<.01). S-nitrosohemoglobin increased measurably after beginning iNO (P<.01), whereas iron nitrosyl hemoglobin and total hemoglobin-bound NO-species compounds did not change.
conclusionTreatment of pulmonary hypertensive infants with iNO results in increases in levels of nitrite, nitrate, and S-nitrosohemoglobin in circulating blood. We speculate that these compounds may be carriers of NO bioactivity throughout the body and account for peripheral effects of iNO in the brain, heart, and other organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.