ArticleHeart rhythm2012
Statin use and postoperative atrial fibrillation after major noncardiac surgery.
Article in Heart rhythm, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Statin use in total joint arthroplasty: a systematic review.Annals of medicine and surgery (2012) · 2024Article
- Exploring postoperative atrial fibrillation after non-cardiac surgery: mechanisms, risk factors, and prevention strategies.Frontiers in cardiovascular medicine · 2023Review
- Perioperative Statin Use May Reduce Postoperative Arrhythmia Rates After Total Joint Arthroplasty.The Journal of arthroplasty · 2021Article
- The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.Current vascular pharmacology · 2019Review
- Response to perioperative statin therapy in cardiac surgery: a matter of race and timing?Journal of thoracic disease · 2016Article
- Initiation patterns of statin therapy among adult patients undergoing intermediate to high-risk non-cardiac surgery.Pharmacoepidemiology and drug safety · 2016Article
- Incidence, predictors, and outcomes associated with postoperative atrial fibrillation after major noncardiac surgery.American heart journal · 2012Article
- Preoperative Statin Use Not Associated With Improved Outcomes After Ascending Aortic Repair.Seminars in thoracic and cardiovascular surgeryArticle
- Statin and Atrial Fibrilation: When does it work?Journal of atrial fibrillationReview
- Age as a Risk factor for Atrial Fibrillation and Flutter after Coronary Artery Bypass Grafting.Journal of atrial fibrillationReview
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5 authors.
Funding
Abstract
backgroundAlthough statin lipid-lowering medications likely reduce perioperative ischemic complications, few data exist to describe statins' effects on risk for and outcomes of atrial fibrillation following noncardiac surgery.
objectiveTo examine the association between treatment with statin medications and clinically significant postoperative atrial fibrillation (POAF) following major noncardiac surgery.
methodsA retrospective cohort study of patients aged 18 years or older who underwent major noncardiac surgery between January 1, 2008, and December 31, 2008. Cases of clinically significant POAF were selected by using a combination of International Classification of Diseases-9 codes and clinical variables. We defined statin users as those whose pharmacy data included a charge for a statin drug on the day of surgery, the day after surgery, or both.
resultsOf 370,447 patients, 10,957 (3.0%) developed clinically significant POAF; overall, 79,871 (21.6%) received a perioperative statin. Patients receiving statins were generally older (68.8 vs 61.1 years; P <.001) and more likely to be receiving a beta-blocker (50.3% vs 21.6%; P < .001). Statin use was associated with a lower unadjusted rate of POAF (2.6% vs 3.0%; P < .001). After adjustment for patient risk factors and surgery type, odds for POAF remained significantly lower among statin-treated patients (adjusted odds ratio = 0.79; 95% confidence interval = 0.71-0.87; P < .001). Statin use was not associated with differences in cost, length of stay, or mortality among patients who developed POAF.
conclusionTreatment with statin agents appears to be associated with a lower risk for clinically significant POAF following major noncardiac surgery.
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