ArticleAmerican journal of human genetics2011
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection.
Article in American journal of human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Sleep quality and associated factors among university students in Africa: a systematic review and meta-analysis study.Frontiers in psychiatry · 2024Pooled it
- Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.American journal of human genetics · 2016Pooled it
- Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.American journal of human genetics · 2013Pooled it
- Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.PloS one · 2012Pooled it
- Article
- The distribution of highly deleterious variants across human ancestry groups.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Population Genomic Scans for Natural Selection and Demography.Annual review of genetics · 2024Review
- Europeans and Americans of European origin show differences between their biological pathways related to the major histocompatibility complex.Scientific reports · 2024Article
- Whole-exome sequencing of Nigerian benign prostatic hyperplasia reveals increased alterations in apoptotic pathways.The Prostate · 2024Article
- A Catalog of Coding Sequence Variations in Salivary Proteins' Genes Occurring during Recent Human Evolution.International journal of molecular sciences · 2023Article
- Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture.Nature genetics · 2023Article
- Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti.Scientific reports · 2022Article
- How HLA diversity is apportioned: influence of selection and relevance to transplantation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies.Journal of human genetics · 2022Article
- A brief history and popularity of methods and tools used to estimate micro-evolutionary forces.Ecology and evolution · 2021Review
- How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans.Human immunology · 2021Article
- Powerful detection of polygenic selection and evidence of environmental adaptation in US beef cattle.PLoS genetics · 2021Article
- Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection.Scientific reports · 2021Article
- Dating admixture events is unsolved problem in multi-way admixed populations.Briefings in bioinformatics · 2020Article
- Distribution of local ancestry and evidence of adaptation in admixed populations.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
40 authors at 20 institutions in 4 countries.
Funding
Abstract
The study of recent natural selection in human populations has important applications to human history and medicine. Positive natural selection drives the increase in beneficial alleles and plays a role in explaining diversity across human populations. By discovering traits subject to positive selection, we can better understand the population level response to environmental pressures including infectious disease. Our study examines unusual population differentiation between three large data sets to detect natural selection. The populations examined, African Americans, Nigerians, and Gambians, are genetically close to one another (F(ST) < 0.01 for all pairs), allowing us to detect selection even with moderate changes in allele frequency. We also develop a tree-based method to pinpoint the population in which selection occurred, incorporating information across populations. Our genome-wide significant results corroborate loci previously reported to be under selection in Africans including HBB and CD36. At the HLA locus on chromosome 6, results suggest the existence of multiple, independent targets of population-specific selective pressure. In addition, we report a genome-wide significant (p = 1.36 × 10(-11)) signal of selection in the prostate stem cell antigen (PSCA) gene. The most significantly differentiated marker in our analysis, rs2920283, is highly differentiated in both Africa and East Asia and has prior genome-wide significant associations to bladder and gastric cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.