ReviewJournal of chromatography. A2012
Silica-based, hyper-crosslinked acid stable stationary phases for high performance liquid chromatography.
Review in Journal of chromatography. A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A new family of hyper-crosslinked (HC) phases for use under very aggressive acid conditions including those encountered in ultra-fast, high temperature two-dimensional liquid chromatography (2DLC) has been recently introduced. This type of stationary phase shows significantly enhanced acid and thermal stability compared to the most acid stable, commercial RPLC phases. In addition, the use of "orthogonal" chemistry to make surface-confined polymer networks ensures good reproducibility and high efficiency. One of the most interesting features of the HC phases is the ability to derivatize the surface aromatic groups with various functional groups. This has led to the development of a family of hyper-crosslinked phases possessing a wide variety of chromatographic selectivities by attaching hydrophobic (e.g. -C₈), ionizable (e.g. -COOH, -SO₃H), aromatic (e.g. -toluene) or polar (e.g. -OH) species to the aromatic polymer network. HC reversed phases with various degrees of hydrophobicity and mixed-mode HC phases with added strong and weak cation exchange sites have been synthesized, characterized and applied. These silica-based acid-stable HC phases, with their attractive chromatographic properties, should be very useful in the separation of bases or biological analytes in acidic media, especially at elevated temperatures. This work reviews prior research on HC phases and introduces a novel HC phase made by alternative chemistry.
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