ArticleJournal of studies on alcohol and drugs2011
Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters.
Article in Journal of studies on alcohol and drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Pooled it
- Outpatient treatment of alcohol use disorders among subjects 60+ years: design of a randomized clinical trial conducted in three countries (Elderly Study).BMC psychiatry · 2015Trial
- Aging successfully, but still vulnerable: Late life experiences of older adults who have recovered from alcohol use disorder.International journal of geriatric psychiatry · 2022Article
- Association of Serotonin Transporter (SERT) Polymorphisms with Opioid Dependence and Dimensional Aspects of Cocaine Use in a Caucasian Cohort of Opioid Users.Neuropsychiatric disease and treatment · 2021Article
- Psychiatric disorders and SLC6A4 gene variants: possible effects on alcohol dependence and alzheimer's disease.Molecular biology reports · 2020Article
- The association betweenNeuropsychiatric disease and treatment · 2019Article
- Social Relationships Moderate Genetic Influences on Heavy Drinking in Young Adulthood.Journal of studies on alcohol and drugs · 2017Article
- Article
- Variation in the Serotonin Transporter Gene and Alcoholism: Risk and Response to Pharmacotherapy.Alcohol and alcoholism (Oxford, Oxfordshire) · 2016Review
- Progression to regular heroin use: examination of patterns, predictors, and consequences.Addictive behaviors · 2015Article
- Civilian stressors associated with alcohol use disorders in the National Guard.American journal of preventive medicine · 2014Article
- Maladaptive decision making and substance use outcomes in high-risk individuals: preliminary evidence for the role of 5-HTTLPR variation.Journal of studies on alcohol and drugs · 2014Article
- Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults.Behavior genetics · 2013Article
- Longitudinal modeling of transmissible risk in boys who subsequently develop cannabis use disorder.The American journal of drug and alcohol abuse · 2013Article
- Assessment of a modified DSM-5 diagnosis of alcohol use disorder in a genetically informative population.Alcoholism, clinical and experimental research · 2013Article
- Age of alcohol and cannabis use onset mediates the association of transmissible risk in childhood and development of alcohol and cannabis disorders: evidence for common liability.Experimental and clinical psychopharmacology · 2013Article
- Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function.Frontiers in psychiatry · 2013Article
- Biology and genetics of prions causing neurodegeneration.Annual review of genetics · 2013Review
- Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse.Substance abuse and rehabilitation · 2012Article
- Application of person-centered medicine in addiction.International journal of person centered medicine · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveSeveral theoretical typology models have been proposed to classify alcoholism into more homogeneous subtypes using various criteria, for which age at onset of alcohol dependence is shared across many models. We investigated the evidence for the distinction between early- versus late-onset alcoholism by examining relevant phenotypic and genotypic variables.
methodData are from 1,248 individuals with alcohol dependence, who were interviewed to collect detailed clinical information. Early versus late onset of alcohol dependence was defined by the age at onset of 22 years. Odds ratio (OR) and Cohen's d were calculated as effect size for comparisons of clinical features between the two groups. We adjusted interviewed age and gender in logistic regression models. Case-control genetic analyses were conducted for the association between HTR1B, SLC6A4, DRD2, and OPRμ1 genes and subgroups of alcohol dependence using a sample of 530 controls screened for alcohol problems.
resultsEarly-onset alcoholism exhibited significantly (p < .01) different clinical characteristics from late-onset alcoholism, including higher severity in alcohol dependence symptoms (d = 0.22) and maximum drinking quantity within 24 hours (d = 0.40), more rapid progression from regular drinking to meet alcohol dependence diagnosis (d = 1.73), higher expectancies for alcohol (d = 0.22-0.47), more comorbidity with externalizing disorders (ORs = 2.8-2.9), and greater prevalence of family alcohol use problems (d = 0.26-0.43). In addition, markers in the HTR1B and OPRμ1 genes showed genetic associations with subgroups of alcohol dependence (ORs = 1.5-2.4).
conclusionsOur findings support that subgroups of alcohol dependence defined by onset age have phenotypic and genetic differences. The early-onset subgroup had more severe features for almost every aspect we examined. Coupled with genetic association findings, age at onset of alcohol dependence may serve as a simple but important clinical marker with implications for future etiological research and intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.