ArticleClinical proteomics2010
Proteomic profiling of the mesenteric lymph after hemorrhagic shock: Differential gel electrophoresis and mass spectrometry analysis.
Article in Clinical proteomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Protein expression profiles of human lymph and plasma mapped by 2D-DIGE and 1D SDS-PAGE coupled with nanoLC-ESI-MS/MS bottom-up proteomics.Journal of proteomics · 2013Trial
- Nanotechnologies for Physiology-Informed Drug Delivery to the Lymphatic System.Annual review of biomedical engineering · 2023Review
- DIGE Analysis Software and Protein Identification Approaches.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Contribution of the plasma and lymph Degradome and Peptidome to the MHC Ligandome.Immunogenetics · 2019Review
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity.The Journal of biological chemistry · 2016Article
- TACTIC: Trans-Agency Consortium for Trauma-Induced Coagulopathy.Journal of thrombosis and haemostasis : JTH · 2015Review
- Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients.Shock (Augusta, Ga.) · 2014Article
- Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry.Shock (Augusta, Ga.) · 2014Article
- A proteomic analysis of the endometrium in obese and overweight women with recurrent miscarriage: preliminary evidence for an endometrial defect.Reproductive biology and endocrinology : RB&E · 2014Article
- The lymph self-antigen repertoire.Frontiers in immunology · 2013Review
- Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury.Physiological reports · 2013Article
- Carrying yourself: self antigen composition of the lymphatic fluid.Lymphatic research and biology · 2013Article
- Plasma proteomics of differential outcome to long-term therapy in children with idiopathic pulmonary arterial hypertension.Proteomics. Clinical applications · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experiments show that upon traumatic injury the composition of mesenteric lymph changes such that it initiates an immune response that can ultimately result in multiple organ dysfunction syndrome (MODS). To identify candidate protein mediators of this process we carried out a quantitative proteomic study on mesenteric lymph from a well characterized rat shock model. We analyzed three animals using analytical 2D differential gel electrophoresis. Intra-animal variation for the majority of protein spots was minor. Functional clustering of proteins revealed changes arising from several global classes that give novel insight into fundamental mechanisms of MODS. Mass spectrometry based proteomic analysis of proteins in mesenteric lymph can effectively be used to identify candidate mediators and loss of protective agents in shock models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.