Trial reportNutrition journal2011
Salivary secretory immunoglobulin A secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over study.
Trial report in Nutrition journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Beneficial effects of Chlorella species supplementation in the general population: a GRADE-assessed systematic review and dose-response meta-analysis.Nutrition & diabetes · 2026Pooled it
- The beneficial effects of Chlorella vulgaris supplementation on health-related indices in patients with non-alcoholic fatty liver disease: a GRADE-assessed systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- The Role ofNutrients · 2025Pooled it
- Trial
- Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants.Nutrition journal · 2012Trial
- Recent advances of emergent extraction technologies to enhance bioactive compounds extraction of microalgae-An overview towards application in cosmetics.International journal of cosmetic science · 2026Review
- Algae and Algal Protein in Human Nutrition: A Narrative Review of Health Outcomes from Clinical Studies.Nutrients · 2026Review
- Chlorella vulgaris as a food substitute: Applications and benefits in the food industry.Journal of food science · 2024Review
- Phenethylamine in chlorella alleviates high-fat diet-induced mouse liver damage by regulating generation of methylglyoxal.NPJ science of food · 2021Article
- A Single Dose of MarineAntioxidants (Basel, Switzerland) · 2021Article
- The effects of immunostimulatory herbal supplements on autoimmune skin diseases.Journal of the American Academy of Dermatology · 2021Review
- Potential ofNutrients · 2020Review
- The effect of Chlorella pyrenoidosa supplementation on immune responses to 2 days of intensified training.European journal of nutrition · 2018Article
- Changes in salivary flow rate following Chlorella-derived multicomponent supplementation.Journal of clinical biochemistry and nutrition · 2016Article
- Changes in arterial stiffness and nitric oxide production with Chlorella-derived multicomponent supplementation in middle-aged and older individuals.Journal of clinical biochemistry and nutrition · 2015Article
- Effect of diclazuril on intestinal morphology and SIgA expression in chicken infected with Eimeria tenella.Parasitology research · 2014Article
- Chlorella-derived multicomponent supplementation increases aerobic endurance capacity in young individuals.Journal of clinical biochemistry and nutrition · 2014Article
- Multicomponent supplement containing Chlorella decreases arterial stiffness in healthy young men.Journal of clinical biochemistry and nutrition · 2013Article
- A computational fluid dynamic analysis of peri-bracket salivary flow influencing the microbial and periodontal parameters.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChlorella, a unicellular green alga that grows in fresh water, contains high levels of proteins, vitamins, minerals, and dietary fibers. Some studies have reported favorable immune function-related effects on biological secretions such as blood and breast milk in humans who have ingested a chlorella-derived multicomponent supplement. However, the effects of chlorella-derived supplement on mucosal immune functions remain unclear. The purpose of this study was to investigate whether chlorella ingestion increases the salivary secretory immunoglobulin A (SIgA) secretion in humans using a blind, randomized, crossover study design.
methodsFifteen men took 30 placebo and 30 chlorella tablets per day for 4 weeks separated by a 12-week washout period. Before and after each trial, saliva samples were collected from a sterile cotton ball that was chewed after overnight fasting. Salivary SIgA concentrations were measured using ELISA.
resultsCompliance rates for placebo and chlorella ingestions were 97.0 ± 1.0% and 95.3 ± 1.6%, respectively. No difference was observed in salivary SIgA concentrations before and after placebo ingestion (P = 0.38). However, salivary SIgA concentrations were significantly elevated after chlorella ingestion compared to baseline (P < 0.01). No trial × period interaction was identified for the saliva flow rates. Although the SIgA secretion rate was not affected by placebo ingestion (P = 0.36), it significantly increased after 4-week chlorella ingestion than before intake (P < 0.01).
conclusionsThese results suggest 4-week ingestion of a chlorella-derived multicomponent supplement increases salivary SIgA secretion and possibly improves mucosal immune function in humans.
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