ArticleJournal of proteome research2011
Ookinete-interacting proteins on the microvillar surface are partitioned into detergent resistant membranes of Anopheles gambiae midguts.
Article in Journal of proteome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium.PLoS pathogens · 2013Trial
- Mosquito-based transmission-blocking vaccine candidates for malaria: progress, challenges, and innovations.Molecular biology reports · 2025Review
- Croquemort-scavenger receptor class B 2 (Journal of biosciences · 2025Article
- Melittin as a promising anti-protozoan peptide: current knowledge and future prospects.AMB Express · 2021Review
- Article
- Systems Biology-Based Investigation of Host-Plasmodium Interactions.Trends in parasitology · 2018Review
- Developing transmission-blocking strategies for malaria control.PLoS pathogens · 2017Review
- Arbovirosis and potential transmission blocking vaccines.Parasites & vectors · 2016Review
- Proteomics reveals major components of oogenesis in the reproductive tract of sugar-fed Anopheles aquasalis.Parasitology research · 2016Article
- The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission.Antimicrobial agents and chemotherapy · 2016Article
- Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Article
- Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment.The Journal of biological chemistry · 2014Article
- Antibodies to a single, conserved epitope in Anopheles APN1 inhibit universal transmission of Plasmodium falciparum and Plasmodium vivax malaria.Infection and immunity · 2014Article
- The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types.Journal of proteome research · 2013Article
- Organ-specific splice variants of aquaporin water channel AgAQP1 in the malaria vector Anopheles gambiae.PloS one · 2013Article
- A bioinformatics approach for integrated transcriptomic and proteomic comparative analyses of model and non-sequenced anopheline vectors of human malaria parasites.Molecular & cellular proteomics : MCP · 2013Article
- Comparative susceptibility of different biological forms of Anopheles stephensi to Plasmodium berghei ANKA strain.PloS one · 2013Article
- Proteome analysis of Cry4Ba toxin-interacting Aedes aegypti lipid rafts using geLC-MS/MS.Journal of proteome research · 2012Article
- Structural characterization and inhibition of the Plasmodium Atg8-Atg3 interaction.Journal of structural biology · 2012Article
- Sink or swim: lipid rafts in parasite pathogenesis.Trends in parasitology · 2012Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Lipid raft microdomains, a component of detergent resistant membranes (DRMs), are routinely exploited by pathogens during host-cell entry. Multiple membrane-surface proteins mediate Plasmodium ookinete invasion of the Anopheles midgut, a critical step in the parasite life cycle that is successfully targeted by transmission-blocking vaccines (TBV). Given that lipid rafts are a common feature of host-pathogen interactions, we hypothesized that they promote the partitioning of midgut surface proteins and thus facilitate ookinete invasion. In support of this hypothesis, we found that five of the characterized Anopheles TBV candidates, including the leading Anopheles TBV candidate, AgAPN1, are present in Anopheles gambiae DRMs. Therefore, to extend the repertoire of putative midgut ligands that can be targeted by TBVs, we analyzed midgut DRMs by tandem mass spectrometry. We identified 1452 proteins including several markers of DRMs. Since glycosylphosphotidyl inositol (GPI)-anchored proteins partition to DRMs, we characterized the GPI subproteome of An. gambiae midgut brush-border microvilli and found that 96.9% of the proteins identified in the GPI-anchored fractions were also present in DRMs. Our study vastly expands the number of candidate malarial TBV targets for subsequent analysis by the broader community and provides an inferred role for midgut plasmalemma microdomains in ookinete cell invasion.
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