ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
The tight junction scaffolding protein cingulin regulates neural crest cell migration.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
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- Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions.iScience · 2020Article
- The multifarious regulation of the apical junctional complex.Open biology · 2020Review
- Bioinformatic identification of key candidate genes and pathways in axon regeneration after spinal cord injury in zebrafish.Neural regeneration research · 2020Article
- Tight Junctions in Cell Proliferation.International journal of molecular sciences · 2019Review
- Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis.Epigenetics · 2017Article
- Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT.Journal of cell science · 2015Article
- Neural crest specification by inhibition of the ROCK/Myosin II pathway.Stem cells (Dayton, Ohio) · 2015Article
- Neural crest migration: trailblazing ahead.F1000prime reports · 2015Review
- Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Migratory neural crest cell αN-catenin impacts chick trigeminal ganglia formation.Developmental biology · 2014Article
- Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest.Molecular biology of the cell · 2014Article
- Article
- Riding the crest of the wave: parallels between the neural crest and cancer in epithelial-to-mesenchymal transition and migration.Wiley interdisciplinary reviews. Systems biology and medicineReview
- The tight junction protein claudin-1 influences cranial neural crest cell emigration.Mechanisms of developmentArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neural crest cells give rise to a diverse range of structures during vertebrate development. These cells initially exist in the dorsal neuroepithelium and subsequently acquire the capacity to migrate. Although studies have documented the importance of adherens junctions in regulating neural crest cell migration, little attention has been paid to tight junctions during this process. We now identify the tight junction protein cingulin as a key regulator of neural crest migration. Cingulin knock-down increases the migratory neural crest cell domain, which is correlated with a disruption of the neural tube basal lamina. Overexpression of cingulin also augments neural crest cell migration and is associated with similar basal lamina changes and an expansion of the premigratory neural crest population. Cingulin overexpression causes aberrant ventrolateral neuroepithelial cell delamination, which is linked to laminin loss and a decrease in RhoA. Together, our results highlight a novel function for cingulin in the neural crest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.