ArticleProtein & cell2011
Dscam mutation leads to hydrocephalus and decreased motor function.
Article in Protein & cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Future Directions for Studying the Potential of Mammalian Dscam in Autism Spectrum Disorder and Alzheimer's Disease: Insights from Dose Sensitivity.Molecular neurobiology · 2025Review
- Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis.Frontiers in molecular neuroscience · 2025Review
- Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation.Nature communications · 2024Article
- Altered motor learning and coordination in mouse models of autism spectrum disorder.Frontiers in cellular neuroscience · 2023Review
- DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice.Molecular psychiatry · 2021Article
- Role of DSCAM in the Development of Neural Control of Movement and Locomotion.International journal of molecular sciences · 2021Review
- Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration.Frontiers in cell and developmental biology · 2020Article
- Pex11a deficiency causes dyslipidaemia and obesity in mice.Journal of cellular and molecular medicine · 2019Article
- Age- and speed-dependent modulation of gaits in DSCAMJournal of neurophysiology · 2018Article
- A third copy of the Down syndrome cell adhesion molecule (Dscam) causes synaptic and locomotor dysfunction in Drosophila.Neurobiology of disease · 2018Article
- Autism spectrum disorder: neuropathology and animal models.Acta neuropathologica · 2017Review
- Defective Angiogenesis and Intraretinal Bleeding in Mouse Models With Disrupted Inner Retinal Lamination.Investigative ophthalmology & visual science · 2016Article
- Down syndrome cell adhesion molecule 1: testing for a role in insect immunity, behaviour and reproduction.Royal Society open science · 2016Article
- Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM.Journal of neurophysiology · 2016Article
- Novel axon projection after stress and degeneration in the Dscam mutant retina.Molecular and cellular neurosciences · 2016Article
- Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits.Journal of neurophysiology · 2016Article
- Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains.Behavioural brain research · 2015Article
- AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth.Protein & cell · 2013Article
- DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the immunoglobulin (Ig) superfamily is expressed widely in the nervous system during embryonic development. Previous studies in Drosophila suggest that Dscam plays important roles in neural development including axon branching, dendritic tiling and cell spacing. However, the function of the mammalian DSCAM gene in the formation of the nervous system remains unclear. Here, we show that Dscam ( del17 ) mutant mice exhibit severe hydrocephalus, decreased motor function and impaired motor learning ability. Our data indicate that the mammalian DSCAM gene is critical for the formation of the central nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.