ArticleNeuroradiology2012
The clot burden score, the Boston Acute Stroke Imaging Scale, the cerebral blood volume ASPECTS, and two novel imaging parameters in the prediction of clinical outcome of ischemic stroke patients receiving intravenous thrombolytic therapy.
Article in Neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Utility of perfusion imaging in acute stroke treatment: a systematic review and meta-analysis.Journal of neurointerventional surgery · 2017Pooled it
- Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke.Neuroradiology · 2016Trial
- NIHSS and Large Artery Atherosclerosis Affect Efficacy of Dual Antiplatelet Therapy Versus Alteplase for Minor Stroke.Brain and behavior · 2026Observational
- Artificial intelligence for decision support in acute stroke - current roles and potential.Nature reviews. Neurology · 2020Review
- Does Clot Burden Score on Baseline T2*-MRI Impact Clinical Outcome in Acute Ischemic Stroke Treated with Mechanical Thrombectomy?Journal of stroke · 2019Article
- Nature's Wastebasket: The Role of the External Carotid Artery in Acute Stroke.BMJ case reports · 2018Article
- Computed tomography perfusion-based selection of endovascularly treated acute ischaemic stroke patients - Are there lessons to be learned from the pre-evidence era?The neuroradiology journal · 2017Article
- A simple prediction score system for malignant brain edema progression in large hemispheric infarction.PloS one · 2017Article
- Clot Burden and Collaterals in Anterior Circulation Stroke: Differences Between Single-Phase CTA and Multi-phase 4D-CTA.Clinical neuroradiology · 2016Article
- Performance of CT ASPECTS and Collateral Score in Risk Stratification: Can Target Perfusion Profiles Be Predicted without Perfusion Imaging?AJNR. American journal of neuroradiology · 2016Article
- Prediction of Stent-Retriever Thrombectomy Outcomes by Dynamic Multidetector CT Angiography in Patients with Acute Carotid T or MCA Occlusions.AJNR. American journal of neuroradiology · 2016Article
- Meta-analysis of Vascular Imaging Features to Predict Outcome Following Intravenous rtPA for Acute Ischemic Stroke.Frontiers in neurology · 2016Review
- Determination of the Middle Cerebral Artery Occlusion Length in Acute Stroke: Contribution of 4D CT Angiography and Importance for Thrombolytic Efficacy Prediction.Clinical neuroradiology · 2015Article
- Thrombosis: Novel nanomedical concepts of diagnosis and treatment.World journal of cardiology · 2015Article
- Performance and Predictive Value of a User-Independent Platform for CT Perfusion Analysis: Threshold-Derived Automated Systems Outperform Examiner-Driven Approaches in Outcome Prediction of Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2015Article
- Sensitivity of 3D Gradient Recalled Echo Susceptibility-Weighted Imaging Technique Compared to Computed Tomography Angiography for Detection of Middle Cerebral Artery Thrombus in Acute Stroke.Neurology international · 2014Article
- Toward patient-tailored perfusion thresholds for prediction of stroke outcome.AJNR. American journal of neuroradiology · 2014Article
- Time-resolved assessment of collateral flow using 4D CT angiography in large-vessel occlusion stroke.European radiology · 2014Article
- Predictors of Outcome following Stroke due to Isolated M2 Occlusions.Cerebrovascular diseases extra · 2014Article
- The predictive value of the Boston Acute Stroke Imaging Scale (BASIS) in acute ischemic stroke patients among Chinese population.PloS one · 2014Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecently two classification methods based on the location and the extent of thrombosis detected with CT angiography have been introduced: the Boston Acute Stroke Imaging Scale (BASIS) and the clot burden score (CBS). We studied the performance of BASIS and CBS in predicting good clinical outcome (mRS ≤ 2 at 90 days) in an acute (< 3 h) stroke cohort treated with intravenous thrombolytic therapy.
methodsEighty-three consecutive patients who underwent multimodal CT were analyzed. Binary logistic regression model was used to assess how BASIS, CBS, and cerebral blood volume (CBV) ASPECTS predict favorable clinical outcome. Diagnostic sensitivities and specificities were calculated and compared.
resultsPatients with low CBS and CBV ASPECTS scores and major strokes according to BASIS had significantly higher admission NIHSS scores, larger perfusion defects, and more often poor clinical outcome. In logistic regression analysis, CBV ASPECTS, CBS and BASIS were significantly associated with the clinical outcome. The performance of BASIS improved when patients with thrombosis of the M2 segment of the middle cerebral artery were classified as having minor stroke (M1-BASIS). In the anterior circulation, the sum of CBS and CBV ASPECTS (CBSV) proved to be the most robust predictor of favorable outcome. CBV ASPECTS and CBS had high sensitivity but moderate to poor specificity while BASIS was only moderately sensitive and specific.
conclusionCBS, BASIS, and CBV ASPECTS are statistically robust and sensitive but unspecific predictors of good clinical outcome. Two new derived imaging parameters, CBSV and M1-BASIS, share these properties and may have increased prognostic value.
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