ArticleBiochemistry research international2012
Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells.
Article in Biochemistry research international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity.Diabetologia · 2013Trial
- Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity.Aging and disease · 2025Review
- Identification of new candidate genes affecting drip loss in pigs based on genomics and transcriptomics data.Journal of animal science · 2025Article
- A genome-wide association study for the fatty acid composition of breast meat in an F2 crossbred chicken population.Journal of animal science and technology · 2023Article
- Buspirone Induces Weight Loss and Normalization of Blood Pressure via the Stimulation of PPARPPAR research · 2023Article
- Exploring the growth trait molecular markers in two sheep breeds based on Genome-wide association analysis.PloS one · 2023Article
- Review
- Transcription Factor Movement and Exercise-Induced Mitochondrial Biogenesis in Human Skeletal Muscle: Current Knowledge and Future Perspectives.International journal of molecular sciences · 2022Review
- The role of CD36-Fabp4-PPARγ in skeletal muscle involves insulin resistance in intrauterine growth retardation mice with catch-up growth.BMC endocrine disorders · 2022Article
- Differentially Expressed Hepatic Genes Revealed by Transcriptomics in Pigs with Different Liver Lipid Contents.Oxidative medicine and cellular longevity · 2022Article
- Bezafibrate prevents aging inJournal of animal science and technology · 2021Article
- How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective.Antioxidants (Basel, Switzerland) · 2021Review
- Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.Nature communications · 2019Article
- PGC-1α activation: a therapeutic target for type 2 diabetes?Eating and weight disorders : EWD · 2019Review
- Long-term dietary resveratrol supplementation decreased serum lipids levels, improved intramuscular fat content, and changed the expression of several lipid metabolism-related miRNAs and genes in growing-finishing pigs1.Journal of animal science · 2019Article
- Cyanidin-3-glucoside enhances mitochondrial function and biogenesis in a human hepatocyte cell line.Cytotechnology · 2018Article
- Article
- Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism.Scientific reports · 2018Article
- Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation.Journal of lipid research · 2017Article
- Upregulation of skeletal muscle PGC-1α through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance.Scientific reports · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effects of PGC-1α (peroxisome proliferator-activated receptor γ coactivator-1α) overexpression on the oxidative capacity of human skeletal muscle cells ex vivo. PGC-1α overexpression increased the oxidation rate of palmitic acid and mRNA expression of genes regulating lipid metabolism, mitochondrial biogenesis, and function in human myotubes. Basal and insulin-stimulated deoxyglucose uptake were decreased, possibly due to upregulation of PDK4 mRNA. Expression of fast fiber-type gene marker (MHCIIa) was decreased. Compared to skeletal muscle in vivo, PGC-1α overexpression increased expression of several genes, which were downregulated during the process of cell isolation and culturing. In conclusion, PGC-1α overexpression increased oxidative capacity of cultured myotubes by improving lipid metabolism, increasing expression of genes involved in regulation of mitochondrial function and biogenesis, and decreasing expression of MHCIIa. These results suggest that therapies aimed at increasing PGC-1α expression may have utility in treatment of obesity and obesity-related diseases.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.