ArticleInternational journal of clinical and experimental pathology2011
IL-17 Expression by macrophages is associated with proliferative inflammatory atrophy lesions in prostate cancer patients.
Article in International journal of clinical and experimental pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Olaparib enhancing radiosensitization and anti-metastatic effect of oral cancer by targeting IL-17A signal.Cancer cell international · 2024Article
- The role of interleukin-17 in inflammation-related cancers.Frontiers in immunology · 2024Review
- A Novel Bispecific Anti-IL17/VEGF Fusion Trap Exhibits Potent and Long-Lasting Inhibitory Effects on the Development of Age-Related Macular Degeneration.Biochemistry research international · 2024Article
- Interleukin-17 contributes to Ross River virus-induced arthritis and myositis.PLoS pathogens · 2022Article
- Increase inInternational journal of molecular sciences · 2021Article
- TGF-βR inhibitor SB431542 restores immune suppression induced by regulatory B-T cell axis and decreases tumour burden in murine fibrosarcoma.Cancer immunology, immunotherapy : CII · 2021Article
- Prostate carcinogenesis: inflammatory storms.Nature reviews. Cancer · 2020Review
- IL-17-Producing Cells in Tumor Immunity: Friends or Foes?Immune network · 2020Review
- Expression Levels of IL-17A, IL-17F, IL-17RA, and IL-17RC in Prostate Cancer with Taking into Account the Histological Grade according to Gleason Scale in Comparison to Benign Prostatic Hyperplasia: In Search of New Therapeutic Options.Journal of immunology research · 2020Article
- Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Induces Interleukin-17 Production via Activation of the IRAK1-PI3K-p38MAPK-C/EBPβ/CREB Pathways.Journal of virology · 2019Article
- Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia.International journal of molecular sciences · 2019Review
- Interleukin-17 Promotes Migration and Invasion of Human Cancer Cells Through Upregulation of MTA1 Expression.Frontiers in oncology · 2019Article
- A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family MembersFrontiers in immunology · 2018Article
- The Identification of Macrophage-enriched Glycoproteins Using Glycoproteomics.Molecular & cellular proteomics : MCP · 2017Article
- Article
- Inflammation and prostate cancer: friends or foe?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Review
- Anti-IL-17 therapy restricts and reverses late-term corneal allorejection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression.The Journal of pathology · 2015Article
- Inflammatory Signaling Involved in High-Fat Diet Induced Prostate Diseases.Journal of urology and research · 2015Article
- Interleukin-17 and type 17 helper T cells in cancer management and research.ImmunoTargets and therapy · 2014Review
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Authors and funding
4 authors.
Funding
Abstract
Intraprostatic leukocyte function may vary depending on local inflammatory or malignant cell microenvironment. Interleukin (IL)-17 producing cells play key roles in chronic inflammation and autoimmunity. Little is known about the relevance of IL-17 producing cells at sites of prostate tissue inflammation and/or prostate adenocarcinoma. In this study, we analyzed thirty formalin-fixed paraffin-embedded whole-mount radical prostatectomy specimens of prostate cancer patients. Immunohistochemistry was employed to identify IL-17 producing cells in all sites of mononuclear cell accumulation, noting their relationships to areas of prostate cancer, proliferative inflammatory atrophy (PIA), or hyperplastic benign tissue. Levels of IL-17 producing cells were similar in zones of benign prostate tissue and areas of prostate cancer. Pronounced intraluminal and peri-glandular IL-17 producing cell accumulations were identified in the mononuclear cell infiltrates associated with PIA lesions. Glandular and peri-glandular CD68+ macrophages and neutrophils were the predominant IL-17 producing cells in PIA lesions. The accumulation of IL-17 expressing cells in PIA lesions presents direct evidence of an inflammatory microenvironment that may support the development of prostate cancer.
Indexed as
Identifiers
21904631PMC3160607What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.